X0306 4 2020-01-23 0 0001680581 Fulcrum Therapeutics, Inc. FULC 0001778713 Cadavid Diego C/O FULCRUM THERAPEUTICS, INC. 26 LANDSDOWNE STREET CAMBRIDGE MA 02139 0 1 0 0 SVP Clinical Development Stock Option (right to buy) 16.87 2020-01-23 4 A 0 55440 0.00 A 2030-01-22 Common Stock 55440 55440 D This option was granted on January 23, 2020 and is scheduled to vest in equal quarterly installments over four years beginning on the vesting commencement date of January 1, 2020, subject to continued service. /s/ Peter Thomson, as attorney-in-fact for Diego Cadavid 2020-01-27