The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103   727,001 100,000 SH   SOLE   100,000 0 0
ABEONA THERAPEUTICS INC COM NEW 00289Y206   2,539,846 533,581 SH   SOLE   533,581 0 0
ACLARIS THERAPEUTICS INC COM 00461U105   230,877 150,900 SH   SOLE   150,900 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209   292,345 265,769 SH   SOLE   265,769 0 0
AETHLON MED INC COM NEW 00808Y406   440,084 1,229,285 SH   SOLE   1,229,285 0 0
AKERO THERAPEUTICS INC COM 00973Y108   9,917,600 245,000 SH   SOLE   245,000 0 0
ALECTOR INC COM 014442107   1,168,500 950,000 SH   SOLE   950,000 0 0
ALLAKOS INC COM 01671P100   266,736 1,171,950 SH   SOLE   1,171,950 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   8,531,012 31,594 SH   SOLE   31,594 0 0
ALPHA COGNITION INC COM NEW 02074J501   5,110,337 967,867 SH   SOLE   967,867 0 0
ALPHA TEKNOVA INC COM 02080L102   72,701 14,008 SH   SOLE   14,008 0 0
ALTIMMUNE INC COM NEW 02155H200   1,200,000 240,000 SH Put SOLE   240,000 0 0
ALTO NEUROSCIENCE INC COM SHS 02157Q109   378,001 175,000 SH   SOLE   175,000 0 0
ANEBULO PHARMACEUTICALS INC COM 034569103   205,036 157,720 SH   SOLE   157,720 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   1,640,250 75,000 SH   SOLE   75,000 0 0
APOGEE THERAPEUTICS INC COM 03770N101   2,641,352 70,700 SH Put SOLE   70,700 0 0
ARCELLX INC COMMON STOCK 03940C100   7,320,960 111,600 SH Put SOLE   111,600 0 0
ARCTURUS THERAPEUTICS HLDGS COM 03969T109   1,853,249 175,000 SH   SOLE   175,000 0 0
ARCTURUS THERAPEUTICS HLDGS COM 03969T109   1,588,500 150,000 SH Call SOLE   150,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109   1,282,400 163,363 SH   SOLE   163,363 0 0
ARVINAS INC COM 04335A105   1,613,898 229,900 SH   SOLE   229,900 0 0
AUTONOMIX MED INC COM NEW 05330T205   35,001 20,000 SH   SOLE   20,000 0 0
AVALO THERAPEUTICS INC COM NEW 05338F306   1,602,000 200,000 SH   SOLE   200,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108   8,856,000 300,000 SH Put SOLE   300,000 0 0
BIOHAVEN LTD COM G1110E107   8,370,728 348,200 SH Call SOLE   348,200 0 0
BIOMX INC COM NEW 09090D301   496,226 892,976 SH   SOLE   892,976 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   10,081,644 113,904 SH   SOLE   113,904 0 0
BRIDGEBIO PHARMA INC COM 10806X102   3,140,235 90,837 SH   SOLE   90,837 0 0
BRIDGEBIO PHARMA INC COM 10806X102   22,657,178 655,400 SH Call SOLE   655,400 0 0
BRIGHT MINDS BIOSCIENCES INC COM NEW 10919W405   2,360,097 65,431 SH   SOLE   65,431 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309   3,796,000 400,000 SH Call SOLE   400,000 0 0
CARTESIAN THERAPEUTICS INC COM NEW 816212302   292,149 22,166 SH   SOLE   22,166 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101   6,053,989 249,649 SH   SOLE   249,649 0 0
CELCUITY INC COM 15102K100   403,389 39,900 SH Put SOLE   39,900 0 0
CELCUITY INC COM 15102K100   150,639 14,900 SH Call SOLE   14,900 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   323,070 17,800 SH Put SOLE   17,800 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   323,070 17,800 SH Call SOLE   17,800 0 0
CHANNEL THERAPEUTICS CORPORA COM SHS 171126105   626,004 440,849 SH   SOLE   440,849 0 0
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104   232,226 213,052 SH   SOLE   213,052 0 0
CIDARA THERAPEUTICS INC COM NEW 171757206   5,362,167 248,940 SH   SOLE   248,940 0 0
CLIMB BIO INC COM 28658R106   213,608 175,088 SH   SOLE   175,088 0 0
COMPASS THERAPEUTICS INC COM 20454B104   1,258,180 662,200 SH Put SOLE   662,200 0 0
COMPASS THERAPEUTICS INC COM 20454B104   1,258,180 662,200 SH Call SOLE   662,200 0 0
CORCEPT THERAPEUTICS INC COM 218352102   32,883,938 287,900 SH Put SOLE   287,900 0 0
CORCEPT THERAPEUTICS INC COM 218352102   11,422,000 100,000 SH Call SOLE   100,000 0 0
CORVUS PHARMACEUTICALS INC COM 221015100   159,000 50,000 SH Put SOLE   50,000 0 0
CORVUS PHARMACEUTICALS INC COM 221015100   1,075,158 338,100 SH Call SOLE   338,100 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   17,555,875 523,431 SH   SOLE   523,431 0 0
CUMBERLAND PHARMACEUTICALS I COM 230770109   3,130,200 740,000 SH   SOLE   740,000 0 0
CYBIN INC COM NEW 23256X407   2,518,090 397,175 SH   SOLE   397,175 0 0
CYTOKINETICS INC COM NEW 23282W605   6,027,776 149,982 SH   SOLE   149,982 0 0
DELCATH SYS INC COM NEW 24661P807   1,277,647 100,365 SH   SOLE   100,365 0 0
DISC MEDICINE INC COM 254604101   590,716 11,900 SH Call SOLE   11,900 0 0
DYNE THERAPEUTICS INC COM 26818M108   3,753,434 358,837 SH   SOLE   358,837 0 0
DYNE THERAPEUTICS INC COM 26818M108   1,956,020 187,000 SH Call SOLE   187,000 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   6,160,000 280,000 SH   SOLE   280,000 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101   3,475,499 1,025,221 SH   SOLE   1,025,221 0 0
ELEVATION ONCOLOGY INC COM 28623U101   178,792 690,050 SH   SOLE   690,050 0 0
ELI LILLY & CO COM 532457108   123,886,500 150,000 SH Put SOLE   150,000 0 0
ENLIVEN THERAPEUTICS INC COM 29337E102   5,698,108 289,538 SH   SOLE   289,538 0 0
EVAXION BIOTECH A/S SPONSORED ADS 29970R303   148,000 80,000 SH   SOLE   80,000 0 0
EVOLUS INC COM 30052C107   2,324,979 193,265 SH   SOLE   193,265 0 0
FORTE BIOSCIENCES INC COM NEW 34962G208   4,727,587 609,225 SH   SOLE   609,225 0 0
FULCRUM THERAPEUTICS INC COM 359616109   576,276 200,096 SH   SOLE   200,096 0 0
GERON CORP COM 374163103   238,500 150,000 SH   SOLE   150,000 0 0
GINKGO BIOWORKS HOLDINGS INC CL A NEW 37611X209   332,310 58,300 SH   SOLE   58,300 0 0
HARROW INC COM 415858109   1,550,780 58,300 SH Call SOLE   58,300 0 0
HOOKIPA PHARMA INC COM NEW 43906K209   57,236 52,996 SH   SOLE   52,996 0 0
IBIO INC CON NEW 451033708   2,411,650 599,913 SH   SOLE   599,913 0 0
IMMUNIC INC COM 4525EP101   996,445 914,170 SH   SOLE   914,170 0 0
IMMUNIC INC COM 4525EP101   693,022 635,800 SH Call SOLE   635,800 0 0
IMMUNOVANT INC COM 45258J102   6,836,000 400,000 SH Put SOLE   400,000 0 0
INCYTE CORP COM 45337C102   3,657,220 60,400 SH Call SOLE   60,400 0 0
INHIBRX BIOSCIENCES INC COM 45720N103   589,287 42,122 SH   SOLE   42,122 0 0
INSMED INC COM PAR $.01 457669307   6,469,392 84,800 SH   SOLE   84,800 0 0
ITEOS THERAPEUTICS INC COM 46565G104   469,152 78,585 SH   SOLE   78,585 0 0
JANUX THERAPEUTICS INC COM 47103J105   3,501,657 129,691 SH   SOLE   129,691 0 0
JASPER THERAPEUTICS INC COM NEW 471871202   107,959 25,107 SH   SOLE   25,107 0 0
KARYOPHARM THERAPEUTICS INC COM NEW 48576U205   101,941 27,257 SH   SOLE   27,257 0 0
KEROS THERAPEUTICS INC COM 492327101   2,792,152 274,009 SH   SOLE   274,009 0 0
KEZAR LIFE SCIENCES INC COM NEW 49372L209   521,677 106,901 SH   SOLE   106,901 0 0
KODIAK SCIENCES INC COM 50015M109   1,821,942 649,534 SH   SOLE   649,534 0 0
KYMERA THERAPEUTICS INC COM 501575104   4,839,016 176,800 SH Put SOLE   176,800 0 0
KYMERA THERAPEUTICS INC COM 501575104   2,737,000 100,000 SH Call SOLE   100,000 0 0
LARIMAR THERAPEUTICS INC COM 517125100   125,830 58,526 SH   SOLE   58,526 0 0
LEXEO THERAPEUTICS INC COM 52886X107   1,908,601 550,029 SH   SOLE   550,029 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302   653,393 1,417,952 SH   SOLE   1,417,952 0 0
LYELL IMMUNOPHARMA INC COM 55083R104   471,307 876,037 SH   SOLE   876,037 0 0
LYRA THERAPEUTICS INC COM 55234L105   133,645 1,058,148 SH   SOLE   1,058,148 0 0
MACROGENICS INC COM 556099109   101,691 80,071 SH   SOLE   80,071 0 0
MAZE THERAPEUTICS INC COM 578784100   3,553,368 322,740 SH   SOLE   322,740 0 0
METSERA INC COM 59267L107   4,083,000 150,000 SH   SOLE   150,000 0 0
MIND MEDICINE MINDMED INC COM NEW 60255C885   366,742 62,691 SH   SOLE   62,691 0 0
MINERALYS THERAPEUTICS INC COM 603170101   544,684 34,300 SH Call SOLE   34,300 0 0
MONOPAR THERAPEUTICS INC COM NEW 61023L207   215,111 5,908 SH   SOLE   5,908 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102   633,709 136,575 SH   SOLE   136,575 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   3,692,115 94,500 SH Put SOLE   94,500 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   3,692,115 94,500 SH Call SOLE   94,500 0 0
NEKTAR THERAPEUTICS COM 640268108   1,074,079 1,579,528 SH   SOLE   1,579,528 0 0
NEUMORA THERAPEUTICS INC. COM 640979100   15,457 15,457 SH   SOLE   15,457 0 0
NEURONETICS INC COM 64131A105   4,048,000 1,100,000 SH   SOLE   1,100,000 0 0
NUVATION BIO INC COM CL A 67080N101   1,089,894 619,258 SH   SOLE   619,258 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106   721,897 191,994 SH   SOLE   191,994 0 0
ONKURE THERAPEUTICS INC COM CL A 68277Q105   1,091,143 253,754 SH   SOLE   253,754 0 0
ORUKA THERAPEUTICS INC COM 687604108   1,795,499 175,000 SH   SOLE   175,000 0 0
PEPGEN INC COM 713317105   210,750 150,000 SH   SOLE   150,000 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207   5,510,161 145,502 SH   SOLE   145,502 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   4,836,000 100,000 SH Put SOLE   100,000 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   4,836,000 100,000 SH Call SOLE   100,000 0 0
PROTHENA CORP PLC SHS G72800108   1,237,502 100,000 SH Call SOLE   100,000 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101   600,927 613,253 SH   SOLE   613,253 0 0
RELAY THERAPEUTICS INC COM 75943R102   1,947,467 743,308 SH   SOLE   743,308 0 0
RELMADA THERAPEUTICS INC COM 75955J402   10,873 40,270 SH   SOLE   40,270 0 0
REZOLUTE INC COM NEW 76200L309   145,168 50,058 SH   SOLE   50,058 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   1,480,146 221,911 SH   SOLE   221,911 0 0
SAGIMET BIOSCIENCES INC COM SER A 786700104   39,067 11,984 SH   SOLE   11,984 0 0
SANGAMO THERAPEUTICS INC COM 800677106   1,219,905 1,860,179 SH   SOLE   1,860,179 0 0
SAREPTA THERAPEUTICS INC COM 803607100   10,791,133 169,087 SH   SOLE   169,087 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103   7,850,355 244,179 SH   SOLE   244,179 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103   3,215,000 100,000 SH Call SOLE   100,000 0 0
SENSEI BIOTHERAPEUTICS INC COM 81728A108   177,285 449,963 SH   SOLE   449,963 0 0
SOLENO THERAPEUTICS INC COM 834203309   7,145,000 100,000 SH Put SOLE   100,000 0 0
SOLENO THERAPEUTICS INC COM 834203309   17,362,350 243,000 SH Call SOLE   243,000 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204   851,001 230,000 SH   SOLE   230,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103   13,984,750 25,000 SH   SOLE   25,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103   179,004,800 320,000 SH Put SOLE   320,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   552,464 12,519 SH   SOLE   12,519 0 0
SPRUCE BIOSCIENCES INC COM 85209E109   290,100 1,000,000 SH   SOLE   1,000,000 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106   4,571,311 264,085 SH   SOLE   264,085 0 0
SYNLOGIC INC COM NEW 87166L209   25,323 20,422 SH   SOLE   20,422 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103   24,915,528 485,021 SH   SOLE   485,021 0 0
TECTONIC THERAPEUTIC INC COM 878972108   4,765,584 269,090 SH   SOLE   269,090 0 0
TELADOC HEALTH INC COM 87918A105   1,194,000 150,000 SH   SOLE   150,000 0 0
TERNS PHARMACEUTICALS INC COM 880881107   851,435 308,491 SH   SOLE   308,491 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   3,074,000 200,000 SH Call SOLE   200,000 0 0
TG THERAPEUTICS INC COM 88322Q108   8,282,864 210,065 SH   SOLE   210,065 0 0
THERIVA BIOLOGICS INC COM NEW 87164U508   132,034 120,031 SH   SOLE   120,031 0 0
THIRD HARMONIC BIO INC COM 88427A107   347,001 100,000 SH   SOLE   100,000 0 0
TOURMALINE BIO INC COM 89157D105   1,033,171 67,927 SH   SOLE   67,927 0 0
TRAWS PHARMA INC COM NEW 68232V884   65,534 28,493 SH   SOLE   28,493 0 0
TREVI THERAPEUTICS INC COM 89532M101   3,616,749 575,000 SH   SOLE   575,000 0 0
TRUPANION INC COM 898202106   1,490,800 40,000 SH Put SOLE   40,000 0 0
TRUPANION INC COM 898202106   7,454,000 200,000 SH Call SOLE   200,000 0 0
TYRA BIOSCIENCES INC COM 90240B106   325,500 35,000 SH   SOLE   35,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   7,857,172 216,989 SH   SOLE   216,989 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   3,621,000 100,000 SH Put SOLE   100,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   4,095,351 113,100 SH Call SOLE   113,100 0 0
UNIQURE NV SHS N90064101   3,180,000 300,000 SH Call SOLE   300,000 0 0
VAXCYTE INC COM 92243G108   7,552,000 200,000 SH   SOLE   200,000 0 0
VENTYX BIOSCIENCES INC COM 92332V107   1,400,229 1,217,590 SH   SOLE   1,217,590 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   8,253,700 130,000 SH   SOLE   130,000 0 0
VERU INC COM 92536C103   698,509 1,425,239 SH   SOLE   1,425,239 0 0
VERVE THERAPEUTICS INC COM 92539P101   1,637,857 358,393 SH   SOLE   358,393 0 0
VIGIL NEUROSCIENCE INC COM 92673K108   445,001 250,000 SH   SOLE   250,000 0 0
VIKING THERAPEUTICS INC COM 92686J106   1,207,501 50,000 SH   SOLE   50,000 0 0
VIKING THERAPEUTICS INC COM 92686J106   3,622,500 150,000 SH Call SOLE   150,000 0 0
VIR BIOTECHNOLOGY INC COM 92764N102   6,921,041 1,068,062 SH   SOLE   1,068,062 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   6,671,912 494,949 SH   SOLE   494,949 0 0
VISTAGEN THERAPEUTICS INC COM 92840H400   1,504,259 601,703 SH   SOLE   601,703 0 0
VOYAGER THERAPEUTICS INC COM 92915B106   188,489 55,766 SH   SOLE   55,766 0 0