144 0001955589 XXXXXXXX LIVE 0001776985 BioNTech SE 001-39081 AN DER GOLDGRUBE 12 MAINZ 2M 55131 0049613190840 Poetting Sierk Officer American Depositary Shares representing ordinary shares, no par value per share Berenberg Capital Markets LLC

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150000 12583500.00 239970804 03/11/2026 Nasdaq Global Select Ordinary Shares, no par value per share 11/21/2022 Stock Option Exercise BioNTech SE N 95000 11/21/2022 Stock Option Exercise Ordinary Shares, no par value per share 09/09/2016 Private Transaction Medine GmbH N 55000 11/30/2020 Cash (1) Y The filing of this Form 144 shall not be construed as an admission that the undersigned is an affiliate of the issuer. (1) Payment for securities made in two installments in November 2020, with the final payment made on November 30, 2020. 03/11/2026 /s/ Sierk Poetting