<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001803150</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001776985</issuerCik>
      <issuerName>BioNTech SE</issuerName>
      <secFileNumber>001-39081</secFileNumber>
      <issuerAddress>
        <com:street1>AN DER GOLDGRUBE 12</com:street1>
        <com:city>MAINZ</com:city>
        <com:stateOrCountry>2M</com:stateOrCountry>
        <com:zipCode>55131</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>0049613190840</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Medine GmbH</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
        <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Berenberg Capital Markets LLC</name>
        <address>
          <com:street1>1251 Avenue of the Americas</com:street1>
          <com:street2>53rd Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10020</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>858209</noOfUnitsSold>
      <aggregateMarketValue>93870900.42</aggregateMarketValue>
      <noOfUnitsOutstanding>240455450</noOfUnitsOutstanding>
      <approxSaleDate>02/12/2026</approxSaleDate>
      <securitiesExchangeName>Nasdaq Global Select</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Ordinary Shares, no par value per share</securitiesClassTitle>
      <acquiredDate>11/21/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>BioNTech SE</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>856186</amountOfSecuritiesAcquired>
      <paymentDate>11/21/2022</paymentDate>
      <natureOfPayment>Stock Option Exercise</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Ordinary Shares, no par value per share</securitiesClassTitle>
      <acquiredDate>08/09/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>BioNTech SE</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2023</amountOfSecuritiesAcquired>
      <paymentDate>08/09/2024</paymentDate>
      <natureOfPayment>Stock Option Exercise</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Ugur Sahin</name>
        <address>
          <com:street1>An der Goldgrube 12</com:street1>
          <com:city>Mainz</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>55131</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>01/27/2026</saleDate>
      <amountOfSecuritiesSold>42000</amountOfSecuritiesSold>
      <grossProceeds>5004585.60</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Ugur Sahin</name>
        <address>
          <com:street1>An der Goldgrube 12</com:street1>
          <com:city>Mainz</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>55131</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>01/26/2026</saleDate>
      <amountOfSecuritiesSold>3000</amountOfSecuritiesSold>
      <grossProceeds>354000.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Ugur Sahin</name>
        <address>
          <com:street1>An der Goldgrube 12</com:street1>
          <com:city>Mainz</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>55131</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>01/23/2026</saleDate>
      <amountOfSecuritiesSold>2500</amountOfSecuritiesSold>
      <grossProceeds>295711.50</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Ugur Sahin</name>
        <address>
          <com:street1>An der Goldgrube 12</com:street1>
          <com:city>Mainz</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>55131</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>01/22/2026</saleDate>
      <amountOfSecuritiesSold>62000</amountOfSecuritiesSold>
      <grossProceeds>7451792.40</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Ugur Sahin</name>
        <address>
          <com:street1>An der Goldgrube 12</com:street1>
          <com:city>Mainz</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>55131</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>01/21/2026</saleDate>
      <amountOfSecuritiesSold>24538</amountOfSecuritiesSold>
      <grossProceeds>2737038.98</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Ugur Sahin</name>
        <address>
          <com:street1>An der Goldgrube 12</com:street1>
          <com:city>Mainz</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>55131</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>01/16/2026</saleDate>
      <amountOfSecuritiesSold>23000</amountOfSecuritiesSold>
      <grossProceeds>2507395.60</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Ugur Sahin</name>
        <address>
          <com:street1>An der Goldgrube 12</com:street1>
          <com:city>Mainz</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>55131</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>01/15/2026</saleDate>
      <amountOfSecuritiesSold>1913</amountOfSecuritiesSold>
      <grossProceeds>206044.64</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Ugur Sahin</name>
        <address>
          <com:street1>An der Goldgrube 12</com:street1>
          <com:city>Mainz</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>55131</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>01/14/2026</saleDate>
      <amountOfSecuritiesSold>72970</amountOfSecuritiesSold>
      <grossProceeds>7901797.25</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Ugur Sahin</name>
        <address>
          <com:street1>An der Goldgrube 12</com:street1>
          <com:city>Mainz</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>55131</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>01/13/2026</saleDate>
      <amountOfSecuritiesSold>24000</amountOfSecuritiesSold>
      <grossProceeds>2573198.40</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>The filing of this Form 144 shall not be construed as an admission that the undersigned is an affiliate of the issuer.</remarks>
    <noticeSignature>
      <noticeDate>02/12/2026</noticeDate>
      <signature>/s/ Ugur Sahin</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
