<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001802897</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001776985</issuerCik>
      <issuerName>BioNTech SE</issuerName>
      <secFileNumber>001-39081</secFileNumber>
      <issuerAddress>
        <com:street1>An der Goldgrube 12</com:street1>
        <com:city>Mainz</com:city>
        <com:stateOrCountry>2M</com:stateOrCountry>
        <com:zipCode>55131</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>49613190840</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ATHOS KG</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>J.P. Morgan Securities LLC</name>
        <address>
          <com:street1>390 Madison Avenue - 6th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10017</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>10000</noOfUnitsSold>
      <aggregateMarketValue>1207600</aggregateMarketValue>
      <noOfUnitsOutstanding>237725735</noOfUnitsOutstanding>
      <approxSaleDate>11/26/2024</approxSaleDate>
      <securitiesExchangeName>NASD</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Ordinary Shares, no par value per share</securitiesClassTitle>
      <acquiredDate>01/05/2018</acquiredDate>
      <natureOfAcquisitionTransaction>Private placement</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>BioNTech SE</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>10000</amountOfSecuritiesAcquired>
      <paymentDate>01/05/2018</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>09/13/2024</saleDate>
      <amountOfSecuritiesSold>170000</amountOfSecuritiesSold>
      <grossProceeds>19552584</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>09/16/2024</saleDate>
      <amountOfSecuritiesSold>590000</amountOfSecuritiesSold>
      <grossProceeds>72893611</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>09/17/2024</saleDate>
      <amountOfSecuritiesSold>30162</amountOfSecuritiesSold>
      <grossProceeds>3754792</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>09/18/2024</saleDate>
      <amountOfSecuritiesSold>55605</amountOfSecuritiesSold>
      <grossProceeds>6934500</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>09/25/2024</saleDate>
      <amountOfSecuritiesSold>37943</amountOfSecuritiesSold>
      <grossProceeds>4495107</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>09/27/2024</saleDate>
      <amountOfSecuritiesSold>37204</amountOfSecuritiesSold>
      <grossProceeds>4376679</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>09/30/2024</saleDate>
      <amountOfSecuritiesSold>76114</amountOfSecuritiesSold>
      <grossProceeds>8998197</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>10/01/2024</saleDate>
      <amountOfSecuritiesSold>72086</amountOfSecuritiesSold>
      <grossProceeds>8595657</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>10/02/2024</saleDate>
      <amountOfSecuritiesSold>65200</amountOfSecuritiesSold>
      <grossProceeds>7761193</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>10/03/2024</saleDate>
      <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
      <grossProceeds>5963585</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>10/04/2024</saleDate>
      <amountOfSecuritiesSold>14756</amountOfSecuritiesSold>
      <grossProceeds>1812078</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>10/07/2024</saleDate>
      <amountOfSecuritiesSold>20295</amountOfSecuritiesSold>
      <grossProceeds>2488325</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>10/08/2024</saleDate>
      <amountOfSecuritiesSold>15000</amountOfSecuritiesSold>
      <grossProceeds>1830101</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>10/09/2024</saleDate>
      <amountOfSecuritiesSold>6000</amountOfSecuritiesSold>
      <grossProceeds>714360</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>10/10/2024</saleDate>
      <amountOfSecuritiesSold>20000</amountOfSecuritiesSold>
      <grossProceeds>2349436</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>10/11/2024</saleDate>
      <amountOfSecuritiesSold>40000</amountOfSecuritiesSold>
      <grossProceeds>4805228</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>10/14/2024</saleDate>
      <amountOfSecuritiesSold>25424</amountOfSecuritiesSold>
      <grossProceeds>3071964</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>10/16/2024</saleDate>
      <amountOfSecuritiesSold>8036</amountOfSecuritiesSold>
      <grossProceeds>946154</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>11/25/2024</saleDate>
      <amountOfSecuritiesSold>75000</amountOfSecuritiesSold>
      <grossProceeds>8484750</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>The filing of this Form 144 shall not be construed as an admission that the undersigned is an affiliate of the issuer. All ADS to be sold by AT Impf GmbH.</remarks>
    <noticeSignature>
      <noticeDate>11/26/2024</noticeDate>
      <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for /s/ Thomas Maier /s/ Stephan Sperber</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
