X0306 4 2023-01-03 0 0001157601 MADRIGAL PHARMACEUTICALS, INC. MDGL 0001776196 Lynch Brian Joseph C/O MADRIGAL PHARMACEUTICALS, INC. 200 BARR HARBOR DRIVE, SUITE 200 WEST CONSHOHOCKEN PA 19428 0 1 0 0 SVP and General Counsel Common Stock 2023-01-03 4 M 0 13000 91.79 A 13000 D Common Stock 2023-01-03 4 S 0 600 277.91 D 12400 D Common Stock 2023-01-03 4 S 0 400 279.10 D 12000 D Common Stock 2023-01-03 4 S 0 1800 280.66 D 10200 D Common Stock 2023-01-03 4 S 0 2656 281.97 D 7544 D Common Stock 2023-01-03 4 S 0 2628 282.97 D 4916 D Common Stock 2023-01-03 4 S 0 1549 283.85 D 3367 D Common Stock 2023-01-03 4 S 0 829 285.15 D 2538 D Common Stock 2023-01-03 4 S 0 2038 285.74 D 500 D Common Stock 2023-01-03 4 S 0 400 286.62 D 100 D Common Stock 2023-01-03 4 S 0 100 287.86 D 0 D Common Stock 530 I In IRA Stock Option (Right to Buy) 91.79 2023-01-03 4 M 0 13000 0.00 D 2030-03-05 Common Stock 13000 12000 D All transactions reported herein were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. All shares issued pursuant to the exercise of the options reported herein represent 13,000 shares underlying an overall option award of 32,000 shares. All exercised options had vested. As to the overall option for 32,000 shares, 25% of the shares underlying the option vested on March 5, 2021 and, thereafter, 6.25% of the shares vested, or will vest, on the last day of each successive three-month period, provided the Reporting Person continues in service with the Issuer on each such date. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $277.90 to $277.92, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and the footnotes below. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $279.06 to $279.38, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $280.22 to $281.16, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $281.32 to $282.30, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $282.41 to $283.33, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $283.42 to $284.21, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $284.50 to $285.49, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $285.50 to $286.29, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $286.61 to $286.63, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $287.86 to $287.86, inclusive. /s/ Brian J. Lynch 2023-01-05