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      <amendmentNo>1</amendmentNo>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>09/30/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001776111</issuerCik>
        <issuerName>MBX Biosciences</issuerName>
        <issuerCusip>55287L101</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>11711 North Meridian Street</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Carmel</com:city>
          <com:stateOrCountry>X1</com:stateOrCountry>
          <com:zipCode>46032</com:zipCode>
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      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
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      <reportingPersonName>Wellington Biomedical Innovation Master Investors (Cayman) II, L.P.</reportingPersonName>
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      <classPercent>4.5</classPercent>
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        <issuerName>MBX Biosciences</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>11711 North Meridian Street, Suite 300, Carmel IN 46032</issuerPrincipalExecutiveOfficeAddress>
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        <filingPersonName>
Wellington Biomedical Innovation Master Investors (Cayman) II, L.P.</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>c/o Wellington Management Company LLP, 280 Congress Street, Boston MA 02210</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Delaware</citizenship>
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        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
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    <signatureInformation>
      <reportingPersonName>Wellington Biomedical Innovation Master Investors (Cayman) II, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>Ihsan Speede</signature>
        <title>Authorized Person</title>
        <date>11/12/2025</date>
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    </signatureInformation>
    <signatureComments>
    Wellington Alternative Investments LLC; Its General Partner

        Signature:  Ihsan Speede
        Name/Title: Authorized Person
        Date:       11/12/2025
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