<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3/A</documentType>

    <periodOfReport>2019-05-08</periodOfReport>

    <dateOfOriginalSubmission>2019-05-09</dateOfOriginalSubmission>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001163668</issuerCik>
        <issuerName>SOUTH PLAINS FINANCIAL, INC.</issuerName>
        <issuerTradingSymbol>SPFI</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001774463</rptOwnerCik>
            <rptOwnerName>Campbell Richard D</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>5219 CITY BANK PARKWAY</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUBBOCK</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>79407-3544</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>40712</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>2370000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>[see footnote]</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">1,172 of the shares reported represent restricted stock units that may be settled only by delivery of an equal number of shares of common stock and which are subject to vesting and forfeiture.</footnote>
        <footnote id="F2">Shares owned by James C. Henry and Henry Taw LP but subject to a voting agreement and irrevocable proxy pursuant to which Mr. Campbell exercises voting authority.</footnote>
    </footnotes>

    <remarks>This amended and restated report on Form 3/A is being filed to correct the transaction date originally reported as May 9, 2019 to May 8, 2019, the effective date of the Issuer's Registration Statement on Form S-1 (the &quot;Effective Date&quot;).</remarks>

    <ownerSignature>
        <signatureName>/s/ By Mikella D. Newsom as Attorney-in-Fact for Richard D. Campbell</signatureName>
        <signatureDate>2019-05-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
