Summary of Significant Accounting Policies - Liquidity (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Accounting Policies [Abstract]
Net income (loss)	$ (107,659)	$ (18,114)	$ (72,064)
Net cash used in operating activities	(34,412)	(2,479)	$ (74,867)
Accumulated deficit	(278,951)	(171,292)
Cash and cash equivalents	71,784	27,344
Short-term investments	$ 175,490	$ 72,864