X0306 4 2021-04-09 0 0001652130 Intellia Therapeutics, Inc. NTLA 0001773532 Keresty Georgia C/O INTELLIA THERAPEUTICS, INC. 40 ERIE STREET; SUITE 130 CAMBRIDGE MA 02139 1 0 0 0 Common Stock 2021-04-09 4 A 0 4955 0.00 A 4955 D Stock Option (right to buy) 70.64 2021-04-09 4 A 0 7755 0.00 A 2031-04-08 Common Stock 7755 7755 D Based on a grant of restricted stock units representing a contingent right to receive one share of Intellia common stock for each restricted stock unit. This option was granted on April 9, 2021 with respect to 7,755 shares of Common Stock pursuant to the Intellia Therapeutics, Inc. Amended and Restated 2015 Stock Option and Incentive Plan, with 33 1/3% vesting on April 9, 2022 and the remaining 66 2/3% vesting in 8 substantially equal quarterly installments thereafter. /s/Jose E. Rivera, Attorney-In-Fact 2021-04-13