Exhibit 21.1

Subsidiaries of SpringWorks Therapeutics, Inc.

1. SpringWorks Therapeutics, LLC, a Delaware Limited Liability Company

2. SpringWorks Subsidiary 1, Inc. a Delaware Corporation

3. SpringWorks Subsidiary 2, Inc. a Delaware Corporation

4. SpringWorks Subsidiary 3, Inc. a Delaware Corporation

5. SpringWorks Subsidiary 4, Inc. a Delaware Corporation

6. SpringWorks Therapeutics Operating Company, Inc., a Delaware Corporation