X0306 4 2020-11-06 0001771917 Karuna Therapeutics, Inc. KRTX 0001579829 Ignelzi Troy A. C/O KARUNA THERAPEUTICS, INC. 33 ARCH ST STE 3110 BOSTON MA 02110-1424 false true false false Chief Financial Officer Common Stock 2020-11-06 4 M false 564 9.2 A 5564 D Common Stock 2020-11-06 4 S false 564 108.15 D 5000 D Common Stock 2020-11-09 4 M false 8000 9.2 A 13000 D Common Stock 2020-11-09 4 S false 8000 105.02 D 5000 D Common Stock 2020-11-09 4 M false 1318 9.2 A 6318 D Common Stock 2020-11-09 4 S false 1318 108.26 D 5000 D Common Stock 2020-11-10 4 M false 118 9.2 A 5118 D Common Stock 2020-11-10 4 S false 118 103.48 D 5000 D Option (right to buy) 9.20 2020-11-06 4 M false 564 0 D 2020-03-01 2029-03-21 Common Stock 564 235230 D Option (right to buy) 9.20 2020-11-09 4 M false 8000 0 D 2020-03-01 2029-03-21 Common Stock 8000 227230 D Option (right to buy) 9.20 2020-11-09 4 M false 1318 0 D 2020-03-01 2029-03-21 Common Stock 1318 225912 D Option (right to buy) 9.20 2020-11-10 4 M false 118 0 D 2020-03-01 2029-03-21 Common Stock 118 225794 D The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $108.05 to $109.08, inclusive. The reporting person undertakes to provide to Karuna Therapeutics, Inc., any security holder of Karuna Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4. /s/ Troy Ignelzi 2020-11-10