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        <issuerName>Karuna Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>KRTX</issuerTradingSymbol>
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            <rptOwnerName>PAUL STEVEN M</rptOwnerName>
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            <rptOwnerStreet2>99 HIGH STREET, 26TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>BOSTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02110</rptOwnerZipCode>
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                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>111.97</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2024-03-18</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>D</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
                <footnoteId id="F5"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>146900</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>218.03</value>
                    <footnoteId id="F5"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F8"/>
            </exerciseDate>
            <expirationDate>
                <value>2032-02-16</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>146900</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>187.26</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2024-03-18</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>D</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
                <footnoteId id="F5"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>22800</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>142.74</value>
                    <footnoteId id="F5"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F9"/>
            </exerciseDate>
            <expirationDate>
                <value>2023-02-08</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>22800</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">On March 18, 2024, Bristol-Myers Squibb Company (&quot;Bristol-Myers&quot;) acquired Karuna Therapeutics, Inc. (the &quot;Issuer&quot;) pursuant to a certain Agreement and Plan of Merger, dated as of December 22, 2023 (the &quot;Merger Agreement&quot;), by and among the Issuer, Bristol-Myers and Miramar Merger Sub Inc., a wholly owned subsidiary of Bristol-Myers (&quot;Merger Sub&quot;). In accordance with the Merger Agreement, Merger Sub merged with and into the Issuer (the &quot;Merger&quot;) with the Issuer surviving the Merger as a wholly owned subsidiary of Bristol-Myers.</footnote>
        <footnote id="F2">At the effective time of the Merger, each issued and outstanding share of the Issuer's common stock, $0.0001 par value per share (the &quot;Common Stock&quot;) (other than certain excluded shares of Common Stock) automatically converted into the right to receive $330.00 per share in cash (the &quot;Merger Consideration&quot;), without interest and subject to applicable withholding tax.</footnote>
        <footnote id="F3">Reflects a transfer on March 11, 2024 of 31,518 shares of common stock from the reporting person's direct ownership to a trust of which the reporting person is sole trustee and sole beneficiary. Such transfer was exempt from Section 16 pursuant to Rule 16a-13.</footnote>
        <footnote id="F4">Represents restricted stock units (&quot;RSUs&quot;), each representing a contingent right to receive one share of Common Stock. Pursuant to the Merger Agreement, each outstanding RSU, whether granted under an Issuer stock plan or otherwise, automatically vested (to the extent not previously vested), was cancelled and entitled the holder to receive a one-time lump sum payment in an amount in cash, without interest and subject to deduction for any required tax withholding, equal to (i) the total number of shares of Common Stock subject to such RSU immediately prior to the effective time of the Merger, multiplied by (ii) the Merger Consideration.</footnote>
        <footnote id="F5">Pursuant to the Merger Agreement, outstanding and unexercised options to purchase shares of Common Stock (the &quot;Options&quot;), whether granted under an Issuer stock plan or otherwise, automatically vested (to the extent not previously vested), were cancelled and entitled the holder to receive a one-time lump sum payment in an amount in cash, without interest and subject to deduction for any required tax withholding, equal to (i) the total number of shares of Common Stock subject to such Option multiplied by (ii) the excess, if any, of the Merger Consideration over the exercise price per share of Common Stock under such Option.</footnote>
        <footnote id="F6">These Options are fully vested.</footnote>
        <footnote id="F7">These Options vested as to 25% on February 23, 2022, with the remaining Options to vest in twelve equal three-month installments over the following three years, subject to continued service through such dates.</footnote>
        <footnote id="F8">These Options vested as to 25% on February 16, 2023, with the remaining Options to vest in twelve equal three-month installments over the following three years, subject to continued service through such dates.</footnote>
        <footnote id="F9">These Options vested as to 25% on February 9, 2024, with the remaining Options to vest in twelve equal three-month installments over the following three years, subject to continued service through such dates.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Jason Brown, Attorney-in-Fact</signatureName>
        <signatureDate>2024-03-18</signatureDate>
    </ownerSignature>
</ownershipDocument>
