CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Cash flows from operating activities
Net loss	$ (97,574)	$ (58,218)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	15,507	10,636
Amortization of premiums and accretion of discounts on investment securities	(7,305)	285
Depreciation and amortization expense	327	248
Changes in operating assets and liabilities:
Accrued interest on investment securities	(322)	(65)
Accounts receivable	57	1,750
Prepaid expenses and other current assets	(2,319)	166
Right-of-use assets	465	432
Other non-current assets	(50)	28
Accounts payable	(1,903)	(481)
Accrued expenses	(6,943)	(4,059)
Operating lease liability	(569)	(525)
Net cash used in operating activities	(100,629)	(49,803)
Cash flows from investing activities
Purchases of investment securities	(318,644)	(48,303)
Purchase of short-term investments (certificates of deposit)	(2,033)	0
Maturities of investment securities	293,900	66,099
Acquisition of property and equipment	(714)	0
Net cash provided by investing activities	(27,491)	17,796
Cash flows from financing activities
Proceeds from public offering, net of underwriting discounts and commissions	437,001	0
Payment of offering costs	(119)	(25)
Proceeds from exercise of stock options	5,569	1,282
Net cash provided by financing activities	442,451	1,257
Net increase (decrease) in cash, cash equivalents and restricted cash	314,331	(30,750)
Cash, cash equivalents and restricted cash at beginning of period	248,590	207,214
Cash, cash equivalents and restricted cash at end of period	562,921	176,464
Supplemental disclosures of cash flows information
Deferred offering costs included in accounts payable and accrued expenses	219	0
Purchases of property and equipment included in accounts payable and accrued expenses	$ 133	$ 206