Commitments and Contingencies - Additional Information (Details) ft² in Thousands	1 Months Ended	3 Months Ended
	May 31, 2012 USD ($)	Mar. 31, 2023 USD ($) ft² Milestone $ / ft²	Mar. 31, 2022 USD ($)	Dec. 31, 2022 USD ($)	Mar. 31, 2011 USD ($)
Commitments And Contingencies [Line Items]
Restricted cash, net of current portion		$ 0		$ 261,000
Security deposit		400,000		400,000
Right of use assets, net		4,209,000		4,674,000
Present value of lease liabilities		4,759,000
Sublicense income		654,000	$ 0
Contingency reserves for litigation		$ 0
Intellectual Property License Agreement | Eli Lilly and Company
Commitments And Contingencies [Line Items]
Royalty expiration term	6 years
Number of milestones reached | Milestone		0
Milestone payments		$ 0
License agreement term		15 years
Patent License | PureTech Health
Commitments And Contingencies [Line Items]
Contingent milestone payments payable					$ 10,000,000.0
Development and Regulatory Milestone Payments Under License Agreement		$ 8,000,000.0
Outstanding liabilities		0		$ 0
Maximum | Intellectual Property License Agreement | Eli Lilly and Company
Commitments And Contingencies [Line Items]
Contingent milestone payments payable	$ 16,000,000.0
Commercial milestone payments payable	$ 54,000,000.0
The Arch Street Lease Agreement [Member]
Commitments And Contingencies [Line Items]
Undiscounted cash received		$ 0.5
Office Space | Boston, Massachusetts
Commitments And Contingencies [Line Items]
Sublease area of office space | ft²		25,445
Sublease commencement date		Apr. 01, 2021
Sublease Expiring Date		Dec. 31, 2025
Sublease, initial fixed rental amount per rentable square foot of premises per annum | $ / ft²		1.5
Sublease, initial fixed rental increase amount per rentable square foot each year | $ / ft²		1.6