Nature of the Business and Basis of Presentation - Additional Information (Details) - USD ($)	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Subsidiary Sale Of Stock [Line Items]
Shares issued and sold	2,851,299
Purchase of Additional Shares	371,908
Net proceeds from public offering	$ 436,700,000
Underwriting discounts and commissions	23,000,000.0
Offering expenses	300,000
Common stock value	4,000		$ 3,000
Deferred offering costs	625,000		568,000
Cash flows from operating activities	(100,629,000)	$ (49,803,000)
Accumulated deficit	(661,781,000)		$ (564,207,000)
Cash and cash equivalents and available-for-sale investments	$ 1,474,500,000
Common Stock
Subsidiary Sale Of Stock [Line Items]
Shares issued and sold	2,851,299
Initial Public Offering
Subsidiary Sale Of Stock [Line Items]
Public offering price pre share	$ 161.33