Stock-based Compensation (Tables)

3 Months Ended

Mar. 31, 2023

Share-Based Payment Arrangement [Abstract]

Summary of Stock Option Activity

A summary of the Company’s stock option activity and related information is as follows:

	Number of Shares			Weighted- Average Exercise Price Per Share		Weighted- Average Remaining Contractual Term (Years)		Aggregate Intrinsic Value (in thousands)
Outstanding as of December 31, 2022		5,570,355		$	63.82		7.2	$	744,097
Granted		404,098			191.49
Exercised		(72,815	)		76.47
Forfeited		(91,655	)		150.19
Outstanding as of March 31, 2023		5,809,983		$	71.18		7.1	$	652,227
Options vested and expected to vest as of    March 31, 2023		5,809,983		$	71.18		7.1	$	652,227
Options exercisable as of March 31, 2023		3,836,456		$	36.72		6.3	$	555,962

Summary of Stock-based Compensation Expense

Stock-based compensation expense is classified in the statements of operations for the three months ended March 31, 2023 and 2022 as follows (in thousands):

	Three Months Ended March 31,
	2023		2022
Research and development	$	8,835	$	4,530
General and administrative		6,672		6,106
Total stock-based compensation expense	$	15,507	$	10,636

Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]

A summary of the Company’s restricted stock unit activity and related information is as follows:

	Number of Shares			Weighted- Average Grant Date Fair Value
Unvested as of December 31, 2022		—		$	—
Granted		210,748			191.54
Vested		—			—
Forfeited		(1,315	)		191.79
Unvested as of March 31, 2023		209,433		$	191.54