X0306 4 2019-07-02 0 0001771917 Karuna Therapeutics, Inc. KRTX 0001245624 HEALY JAMES SOFINNOVA INVESTMENTS, INC. 3000 SAND HILL ROAD, 4-250 MENLO PARK CA 94025 1 0 0 0 Common Stock 2019-07-02 4 C 0 1029352 A 1029352 I By Sofinnova Venture Partners X, L.P. Common Stock 2019-07-02 4 P 0 700000 16.00 A 1729352 I By Sofinnova Venture Partners X, L.P. Series B Preferred Stock 2019-07-02 4 C 0 792602 D Common Stock 1029352 0 I By Sofinnova Venture Partners X, L.P The Series B Preferred Stock is convertible into shares of the Issuer's Common Stock on a 1.2987-for-one basis. Upon the closing of the Issuer's initial public offering, all shares of Series B Preferred Stock automatically converted into shares of Common Stock. The Series B Preferred Stock has no expiration date. All shares held by Sofinnova Venture Partners X, L.P. ("SVP X"). Sofinnova Management X, L.L.C. ("SM X"), the general partner of SVP X, may be deemed to have sole voting power, and Dr. Michael F. Powell, Dr. James I. Healy, and Dr. Anand Mehra, the managing members of SM X, may be deemed to have shared power to vote these shares. Such individuals disclaim beneficial ownership of such shares except to the extent of their pecuniary interest therein. /s/ Troy Ignelzi, Attorney-in-Fact 2019-07-02