X0306 4 2019-07-02 0 0001771917 Karuna Therapeutics, Inc. KRTX 0001723174 ARCH Venture Partners IX, LLC 8755 W. HIGGINS ROAD, SUITE 1025 CHICAGO IL 60631 0 0 1 0 0001723173 ARCH Venture Partners IX, L.P. 8755 W. HIGGINS ROAD, SUITE 1025 CHICAGO IL 60631 0 0 1 0 0001723172 ARCH Venture Partners IX Overage, L.P. 8755 W. HIGGINS ROAD, SUITE 1025 CHICAGO IL 60631 0 0 1 0 0001666306 ARCH Venture Fund IX, L.P. 8755 W. HIGGINS ROAD, SUITE 1025 CHICAGO IL 60631 0 0 1 0 0001666307 ARCH Venture Fund IX Overage, L.P. 8755 W. HIGGINS ROAD, SUITE 1025 CHICAGO IL 60631 0 0 1 0 0001219039 CRANDELL KEITH C/O ARCH VENTURE PARTNERS IX, LLC 8755 W. HIGGINS ROAD, SUITE 1025 CHICAGO IL 60631 0 0 1 0 0001219043 BYBEE CLINTON C/O ARCH VENTURE PARTNERS IX, LLC 8755 W. HIGGINS ROAD, SUITE 1025 CHICAGO IL 60631 0 0 1 0 Common Stock 2019-07-02 4 P 0 100000 16.00 A 100000 I See Footnote Common Stock 2019-07-02 4 P 0 100000 16.00 A 100000 I See Footnote Common Stock 2019-07-02 4 C 0 723644 A 823644 I See Footnote Common Stock 2019-07-02 4 C 0 723643 A 823643 I See Footnote Common Stock 2019-07-02 4 C 0 857793 A 1681437 I See Footnote Common Stock 2019-07-02 4 C 0 857792 A 1681435 I See Footnote Series A Preferred Stock 2019-07-02 4 C 0 557207 D Common Stock 723644 0 I See Footnote Series A Preferred Stock 2019-07-02 4 C 0 557206 D Common Stock 723643 0 I See Footnote Series B Preferred Stock 2019-07-02 4 C 0 660502 D Common Stock 857793 0 I See Footnote Series B Preferred Stock 2019-07-02 4 C 0 660501 D Common Stock 857792 0 I See Footnote These shares are directly held by ARCH Venture Fund IX, L.P. ("ARCH IX"). ARCH Venture Partners IX, L.P. ("GPLP"), as the sole general partner of ARCH IX, may be deemed to beneficially own the shares held by ARCH IX. ARCH Venture Partners IX, LLC ("GPLLC"), as the sole general partner of GPLP, may be deemed to beneficially own the shares held by ARCH IX. As managing directors of GPLLC, each of Keith Crandell and Clinton Bybee (the "ARCH Managing Directors"), may be deemed to beneficially own the shares held by ARCH IX. Each of GPLP, GPLLC and the ARCH Managing Directors disclaims beneficial ownership of the securities reported herein, except to the extent of their pecuniary interest therein, if any. These shares are directly held by ARCH Venture Fund IX Overage, L.P. ("ARCH Overage"). ARCH Venture Partners IX Overage, L.P. ("Overage GPLP"), as the sole general partner of ARCH Overage, may be deemed to beneficially own the shares held by ARCH Overage. GPLLC, as the sole general partner of Overage GPLP, may be deemed to beneficially own the shares held by ARCH Overage. As managing directors of GPLLC, each of the ARCH Managing Directors may be deemed to beneficially own the shares held by ARCH Overage. Each of Overage GPLP, GPLLC and the ARCH Managing Directors disclaims beneficial ownership of the securities reported herein, except to the extent of their pecuniary interest therein, if any. The Series A Preferred Stock is convertible into shares of the Issuer's Common Stock on a 1.2987-for-one basis. Upon the closing of the Issuer's initial public offering, all shares of Series A Preferred Stock automatically converted into shares of Common Stock. The Series A Preferred Stock has no expiration date. The Series B Preferred Stock is convertible into shares of the Issuer's Common Stock on a 1.2987-for-one basis. Upon the closing of the Issuer's initial public offering, all shares of Series B Preferred Stock automatically converted into shares of Common Stock. The Series B Preferred Stock has no expiration date. ARCH Venture Partners IX, LLC, By: /s/ Mark McDonnell 2019-07-02 ARCH Venture Partners IX, L.P., By: ARCH Venture Partners IX, LLC, its General Partner, By: /s/ Mark McDonnell 2019-07-02 ARCH Venture Partners IX Overage, L.P., By: ARCH Venture Partners IX, LLC, its General Partner, By: /s/ Mark McDonnell 2019-07-02 ARCH Venture Fund IX, L.P., By: ARCH Venture Partners IX, L.P., its General Partner, By: ARCH Venture Partners IX, LLC, its General Partner, By: /s/ Mark McDonnell 2019-07-02 ARCH Venture Fund IX Overage, L.P., By: ARCH Venture Partners IX Overage, L.P., its General Partner, By: ARCH Venture Partners IX, LLC, its General Partner, By: /s/ Mark McDonnell 2019-07-02 Keith Crandell, Managing Director, By: /s/ Mark McDonnell 2019-07-02 Clinton Bybee, Managing Director, By: /s/ Mark McDonnell 2019-07-02