X0306 4 2019-06-27 0 0001771917 Karuna Therapeutics, Inc. KRTX 0001237564 PAUL STEVEN M C/O KARUNA THERAPEUTICS, INC. 33 ARCH STREET, SUITE 3110 BOSTON MA 02110 1 1 0 0 President & CEO Common Stock 2019-06-28 4 P 0 6800 22.86 A 6800 D Common Stock 2019-06-28 4 P 0 3200 23.43 A 10000 D Stock Option (Right to Buy) 16.00 2019-06-27 4 A 0 616703 0.00 D 2019-06-27 Common Stock 616703 616703 D Stock Option (Right to Buy) 20.02 2019-06-28 4 A 0 71121 0.00 D 2019-06-28 Common Stock 71121 71121 D The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $22.31 to $23.21, inclusive. The reporting person undertakes to provide to Karuna Therapeutics, Inc., any security holder of Karuna Therapeutics, Inc., or the staff at the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $23.35 to $23.48, inclusive. The reporting person undertakes to provide to Karuna Therapeutics, Inc., any security holder of Karuna Therapeutics, Inc., or the staff at the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. At time of each grant, 65% of the shares underlying the grant were vested, with the remaining vesting in equal monthly installments through June 15, 2021. /s/ Troy Ignelzi, Attorney-in-Fact 2019-07-01