<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001971187</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001770787</issuerCik>
      <issuerName>10x Genomics, Inc.</issuerName>
      <secFileNumber>001-39035</secFileNumber>
      <issuerAddress>
        <com:street1>6230 STONERIDGE MALL ROAD</com:street1>
        <com:city>PLEASANTON</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94588</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(925) 401-7300</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Taich Adam</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Services</name>
        <address>
          <com:street1>200 W Civic Center Dr., 4th Floor</com:street1>
          <com:city>Sandy</com:city>
          <com:stateOrCountry>UT</com:stateOrCountry>
          <com:zipCode>84070</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>11312</noOfUnitsSold>
      <aggregateMarketValue>207462.08</aggregateMarketValue>
      <noOfUnitsOutstanding>116474179</noOfUnitsOutstanding>
      <approxSaleDate>11/24/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>11/21/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Unit Grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>23767</amountOfSecuritiesAcquired>
      <paymentDate>11/21/2025</paymentDate>
      <natureOfPayment>Services Rendered</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>11/24/2025</noticeDate>
      <signature>Eric S. Whitaker, as Attorney-in-Fact for Adam Taich</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
