<?xml version="1.0" encoding="UTF-8"?><own:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:own="http://www.sec.gov/edgar/ownership">
  <!-- Generated by Workiva -->
  <own:headerData>
    <own:submissionType>144</own:submissionType>
    <own:filerInfo>
      <own:filer>
        <own:filerCredentials>
          <own:cik>0001713070</own:cik>
          <own:ccc>XXXXXXXX</own:ccc>
        </own:filerCredentials>
      </own:filer>
      <own:liveTestFlag>LIVE</own:liveTestFlag>



    </own:filerInfo>
  </own:headerData>
  <own:formData>
    <own:issuerInfo>
      <own:issuerCik>0001770787</own:issuerCik>
      <own:issuerName>10X Genomics, Inc.</own:issuerName>
      <own:secFileNumber>001-39035</own:secFileNumber>
      <own:issuerAddress>
        <com:street1>6230 Stoneridge Mall Road</com:street1>
        <com:city>Pleasanton</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94588</com:zipCode>
      </own:issuerAddress>
      <own:issuerContactPhone>925-401-7300</own:issuerContactPhone>
      <own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Shehnaaz Suliman</own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <own:relationshipsToIssuer>
        <own:relationshipToIssuer>Affiliate</own:relationshipToIssuer>
      </own:relationshipsToIssuer>
    </own:issuerInfo>
    <own:securitiesInformation>
      <own:securitiesClassTitle>Class A Common</own:securitiesClassTitle>
      <own:brokerOrMarketmakerDetails>
        <own:name>JP Morgan Securities LLC</own:name>
        <own:address>
          <com:street1>270 Park Avenue, 10th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10017</com:zipCode>
        </own:address>
      </own:brokerOrMarketmakerDetails>
      <own:noOfUnitsSold>5723</own:noOfUnitsSold>
      <own:aggregateMarketValue>452689.2</own:aggregateMarketValue>
      <own:noOfUnitsOutstanding>120212296</own:noOfUnitsOutstanding>
      <own:approxSaleDate>09/22/2026</own:approxSaleDate>
      <own:securitiesExchangeName>Nasdaq</own:securitiesExchangeName>
    </own:securitiesInformation>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Class A Common</own:securitiesClassTitle>
      <own:acquiredDate>08/21/2024</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>RSU Vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>5723</own:amountOfSecuritiesAcquired>
      <own:paymentDate>08/21/2024</own:paymentDate>
      <own:natureOfPayment>Compensation</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</own:nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>Shehnaaz Suliman</own:name>
        <own:address>
          <com:street1>Care of TXG Genomics Inc</com:street1>
          <com:street2>6230 Stoneridge Mall Road</com:street2>
          <com:city>Pleasanton</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94588</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Class A Common</own:securitiesClassTitle>
      <own:saleDate>08/24/2026</own:saleDate>
      <own:amountOfSecuritiesSold>5723</own:amountOfSecuritiesSold>
      <own:grossProceeds>140477.91</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:remarks>The shares represented on this filing were acquired via RSU award between 08/21/24 and 05/21/25.</own:remarks>
    <own:noticeSignature>
      <own:noticeDate>09/22/2026</own:noticeDate>
      <own:planAdoptionDates>
        <own:planAdoptionDate>03/13/2026</own:planAdoptionDate>
      </own:planAdoptionDates>
      <own:signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Shehnaaz Suliman</own:signature>
    </own:noticeSignature>
  </own:formData>
</own:edgarSubmission>
