X0306 4 2022-05-16 0 0001770787 10x Genomics, Inc. TXG 0001651325 Kosaraju Sridhar C/O 10X GENOMICS, INC. 6230 STONERIDGE MALL ROAD PLEASANTON CA 94588 1 0 0 0 Class A Common Stock 2022-05-16 4 M 0 15000 11.48 A 18458 D Class A Common Stock 3000 I See footnote (1) Stock Option (right to buy) 11.48 2022-05-16 4 M 0 15000 0 D 2029-05-10 Class A Common Stock 15000 94167 D These shares are held by the Kosaraju Family Trust dated June 21, 2014, of which the Reporting Person is trustee. This option, originally for 130,000 shares, of which 35,833 have been exercised, vested as to one forty-eighth of the shares on April 29, 2019, and one-forty-eighth of the shares subject to the option vest each month thereafter, subject to the Reporting Person continuing as a service provider through each such date. This option may be exercised prior to vesting, subject to the Issuer's right to repurchase unvested shares. /s/ Eric S. Whitaker, as Attorney-in-Fact for Sridhar Kosaraju 2022-05-17