X0306 4 2021-08-02 0 0001770787 10x Genomics, Inc. TXG 0001786386 McAnear Justin J. C/O 10X GENOMICS, INC. 6230 STONERIDGE MALL ROAD PLEASANTON CA 94588 0 1 0 0 Chief Financial Officer Class A Common Stock 2021-08-02 4 M 0 10000 5.04 A 49370 D Class A Common Stock 2021-08-02 4 S 0 1698 178.3509 D 47672 D Class A Common Stock 2021-08-02 4 S 0 2202 179.2825 D 45470 D Class A Common Stock 2021-08-02 4 S 0 2298 180.289 D 43172 D Class A Common Stock 2021-08-02 4 S 0 2302 181.3101 D 40870 D Class A Common Stock 2021-08-02 4 S 0 700 182.1629 D 40170 D Class A Common Stock 2021-08-02 4 S 0 500 183.30 D 39670 D Class A Common Stock 2021-08-02 4 S 0 300 184.5233 D 39370 D Stock Option (right to buy) 5.04 2021-08-02 4 M 0 10000 0.00 D 2028-11-02 Class A Common Stock 10000 400159 D This option exercise and the sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person. This transaction was executed in multiple trades at prices ranging from $177.80 to $178.74. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $178.865 to $179.85. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $179.89 to $180.865. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $180.89 to $181.87. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $181.93 to $182.45. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $182.93 to $183.62. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $184.19 to $184.99. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This option, originally for 600,000 shares, of which 199,841 shares have been exercised, vested as to one-fourth of the shares on October 8, 2019 and one forty-eighth of the shares subject to the option vest each month thereafter, subject to the Reporting Person continuing as a service provider through each such date. /s/ Eric S. Whitaker, as Attorney-in-Fact 2021-08-04