X0306 4 2022-11-01 0001770141 UpHealth, Inc. UPH 0001866483 Balakrishnan Ramesh C/O UPHEALTH, INC. 14000 S. MILITARY TRAIL, SUITE 203 DELRAY BEACH FL 33484 0 1 0 0 Pres. & Chief Strategy Officer Common Stock 7578672 D Common Stock 2022-11-01 4 F 0 17243 0.5251 D 7561429 D Includes Restricted Stock Units ("Prior RSUs") of UpHealth, Inc. (the "Company"), that are subject to vesting pursuant to previously disclosed vesting schedules. The Company may withhold shares of stock subject to the Prior RSUs at the time of vesting for the purposes of satisfying any tax withholding obligations which arise in connection with the vesting of such Prior RSUs issued to Reporting Person. /s/ Ramesh Balakrishnan 2022-11-03