<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2022-07-08</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <issuer>
        <issuerCik>0001770141</issuerCik>
        <issuerName>UpHealth, Inc.</issuerName>
        <issuerTradingSymbol>UPH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001864152</rptOwnerCik>
            <rptOwnerName>Bar-Siman-Tov Moshe</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O UPHEALTH, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>14000 S. MILITARY TRAIL SUITE 203</rptOwnerStreet2>
            <rptOwnerCity>DELRAY BEACH</rptOwnerCity>
            <rptOwnerState>FL</rptOwnerState>
            <rptOwnerZipCode>33484</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <remarks>The reporting person's status as an insider terminated as of July 8, 2022 and that the reporting person therefore is no longer subject to Section 16.</remarks>

    <ownerSignature>
        <signatureName>/s/ Moshe Bar-Siman-Tov</signatureName>
        <signatureDate>2022-07-12</signatureDate>
    </ownerSignature>
</ownershipDocument>
