X0306 4 2022-01-10 0001770141 UpHealth, Inc. UPH 0001865843 Gatmaitan Alfonso 14000 MILITARY TRAIL #203 DELRAY BEACH FL 33484 0 1 0 0 Chief Operating Officer Common Stock 1235274 D Common Stock 2022-01-10 4 D 0 51814 0 D 1183460 D Performance-Based Restricted Stock Unit 0.00 2022-01-10 4 D 0 155440 0 D Common Stock 155440 0 D The reporting person resigned as chief operating officer (the "Resignation") of UpHealth, Inc. (the "Company") effective January 10, 2022 (the "Resignation Date"). As a result, the reporting person is no longer subject to Section 16 in connection with his transactions in the equity securities of the Company and therefore will no longer report any such transactions on Form 4 or Form 5. On Resignation Date, the reporting person and the Company entered into a Separation Agreement, whereby within ten days of January 18, 2022 (the "Effective Date"), so long as the Separation Agreement has not been revoked by either party before the Effective Date, the reporting person will vest restricted stock units ("RSUs") for 103,627 shares of the total of 310,881 RSUs that were previously reported by the reporting person on October 20, 2021. All remaining RSUs shall be forfeited as of the Resignation Date. /s/ Alfonso Gatmaitan 2022-01-12