X0306 4/A 2021-08-12 2021-08-16 0001770141 UpHealth, Inc. UPH 0001235685 REY-GIRAUD AGNES C/O UPHEALTH, INC. 14000 S. MILITARY TRAIL SUITE 203 DELRAY BEACH FL 33484 1 0 0 0 Common Stock 2021-08-12 4 A 0 67327 0 A 72327 D Subject to the Reporting Person's continued service to the Company, 1/3 of the Restricted Stock Units ("RSUs") shall vest on May 1, 2022, and the remaining 2/3 of the RSUs shall vest quarterly on each of August 1, November 1, February 1, and May 1 through May 1, 2024; all RSUs shall immediately vest in the event of a Change of Control (as defined in the UpHealth, Inc. 2021 Equity Incentive Plan) of the Company. Includes an aggregate of 67,327 RSUs, of which 1/3 of the RSUs shall vest on May 1, 2022, and the remaining 2/3 of the RSUs shall vest quarterly on each of August 1, November 1, February 1, and May 1 through May 1, 2024. /s/ Agnes Rey-Giraud 2021-08-19