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  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001724939</cik>
          <ccc>XXXXXXXX</ccc>
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      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



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  <formData>
    <issuerInfo>
      <issuerCik>0001770121</issuerCik>
      <issuerName>Sana Biotechnology</issuerName>
      <secFileNumber>001-39941</secFileNumber>
      <issuerAddress>
        <com:street1>188 East Blaine St, Ste 400</com:street1>
        <com:city>Seattle</com:city>
        <com:stateOrCountry>WA</com:stateOrCountry>
        <com:zipCode>98102</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>206-701-7914</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Flagship V Venturelabs RX Fund, L.P.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Affiliate</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>J.P. Morgan Securities LLC</name>
        <address>
          <com:street1>390 Madison Avenue</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10017</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>39830</noOfUnitsSold>
      <aggregateMarketValue>254514</aggregateMarketValue>
      <noOfUnitsOutstanding>191500944</noOfUnitsOutstanding>
      <approxSaleDate>06/07/2023</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/12/2017</acquiredDate>
      <natureOfAcquisitionTransaction>Venture Capital Investment</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>39830</amountOfSecuritiesAcquired>
      <paymentDate>05/12/2017</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>FLAGSHIP VENTURES FUND V, L.P.</name>
        <address>
          <com:street1>188 East Blaine St, Ste 400</com:street1>
          <com:city>Seattle</com:city>
          <com:stateOrCountry>WA</com:stateOrCountry>
          <com:zipCode>98102</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/24/2023</saleDate>
      <amountOfSecuritiesSold>39580</amountOfSecuritiesSold>
      <grossProceeds>257469</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>FLAGSHIP VENTURES FUND V, L.P.</name>
        <address>
          <com:street1>188 East Blaine St, Ste 400</com:street1>
          <com:city>Seattle</com:city>
          <com:stateOrCountry>WA</com:stateOrCountry>
          <com:zipCode>98102</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/25/2023</saleDate>
      <amountOfSecuritiesSold>13127</amountOfSecuritiesSold>
      <grossProceeds>82724</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>FLAGSHIP VENTURES FUND V, L.P.</name>
        <address>
          <com:street1>188 East Blaine St, Ste 400</com:street1>
          <com:city>Seattle</com:city>
          <com:stateOrCountry>WA</com:stateOrCountry>
          <com:zipCode>98102</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/26/2023</saleDate>
      <amountOfSecuritiesSold>9330</amountOfSecuritiesSold>
      <grossProceeds>57621</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>FLAGSHIP VENTURES FUND V, L.P.</name>
        <address>
          <com:street1>188 East Blaine St, Ste 400</com:street1>
          <com:city>Seattle</com:city>
          <com:stateOrCountry>WA</com:stateOrCountry>
          <com:zipCode>98102</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/06/2023</saleDate>
      <amountOfSecuritiesSold>22297</amountOfSecuritiesSold>
      <grossProceeds>140607</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>06/07/2023</noticeDate>
      <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Flagship V Venturelabs RX Fund, L.P.</signature>
    </noticeSignature>
  </formData>
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