Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
OPERATING ACTIVITIES:
Net loss	$ (82,123)	$ (31,448)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	4,346	3,614
Stock-based compensation expense	8,751	7,755
Change in the estimated fair value of contingent consideration	5,460	(528)
Change in the estimated fair value of success payment liabilities	(5,340)	(54,910)
Non-cash expense for operating lease right-of-use assets	3,354	2,606
Other non-cash items, net	(2,913)	(1,437)
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(106)	(3,191)
Operating lease right-of-use assets and liabilities	(8)	372
Accounts payable	(354)	1,917
Accrued expenses and other liabilities	(10,339)	(2,459)
Net cash used in operating activities	(79,272)	(77,709)
INVESTING ACTIVITIES:
Purchases of marketable securities	(20,431)	(25,675)
Proceeds from maturities of marketable securities	85,334	45,753
Purchases of property and equipment	(2,176)	(7,533)
Net cash provided by investing activities	62,727	12,545
FINANCING ACTIVITIES:
Proceeds from issuance of common stock, net	236	652
Net cash provided by financing activities	236	652
Net decrease in cash, cash equivalents, and restricted cash	(16,309)	(64,512)
Cash, cash equivalents, and restricted cash at beginning of period	187,273	261,848
Cash, cash equivalents, and restricted cash at end of period	170,964	197,336
SUPPLEMENTAL CASH FLOW INFORMATION:
Operating lease right-of-use assets obtained in exchange for lease obligations	8,984	3,431
Purchases of property and equipment included in accounts payable and accrued liabilities	$ 968	3,425
Cash received for amounts related to tenant improvement allowances		$ 541