Income Taxes - Additional Information (Detail) $ in Thousands	12 Months Ended
	Dec. 31, 2022 USD ($)
Income Taxes [Line Items]
Net operating loss carryforwards, federal	$ 120,200
Net operating loss carryforwards, state	34,600
Deferred tax asset capitalized research and development	$ 49,687
State
Income Taxes [Line Items]
Net tax operating losses, expiration	begin to expire in 2036
Tax credit carryforward, expiration	begin to expire in 2037
Research tax credits	$ 13,300
Federal
Income Taxes [Line Items]
Research tax credits	30,800
Federal net operating losses, indefinite life	$ 118,600