Condensed Consolidated Statements of Convertible Preferred Stock and Stockholders' Equity (Unaudited) - USD ($) shares in Thousands, $ in Thousands	Total	IPO	At The Market Offering	Convertible Preferred Stock	Common Stock	Common Stock IPO	Common Stock At The Market Offering	Additional Paid-in Capital	Additional Paid-in Capital IPO	Additional Paid-in Capital At The Market Offering	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Beginning balance at Dec. 31, 2020	$ (421,184)				$ 2			$ 8,216			$ 30	$ (429,432)
Beginning balance (in shares) at Dec. 31, 2020				134,113
Beginning balance at Dec. 31, 2020				$ 852,897
Beginning balance (in shares) at Dec. 31, 2020					16,170
Conversion of convertible preferred stock into common stock upon initial public offering	852,897				$ 13			852,884
Conversion of convertible preferred stock into common stock, upon initial public offering (in shares)				(134,113)
Conversion of convertible preferred stock into common stock, upon initial public offering				$ (852,897)
Conversion of convertible preferred stock into common stock, upon initial public offering (in shares)					134,113
Issuance of common stock, net of offering costs		$ 626,405				$ 3			$ 626,402
Issuance of common stock, net of offering costs (in shares)						27,025
Vesting of restricted stock (in shares)					1,428
Exercise of stock options	298							298
Exercise of stock options (in shares)					205
Stock-based compensation expense	4,158							4,158
Unrealized gain (loss) on marketable securities, net	26										26
Net income (loss)	(180,617)											(180,617)
Ending balance at Mar. 31, 2021	881,983				$ 18			1,491,958			56	(610,049)
Ending balance (in shares) at Mar. 31, 2021					178,941
Beginning balance at Dec. 31, 2020	(421,184)				$ 2			8,216			30	(429,432)
Beginning balance (in shares) at Dec. 31, 2020				134,113
Beginning balance at Dec. 31, 2020				$ 852,897
Beginning balance (in shares) at Dec. 31, 2020					16,170
Net income (loss)	(245,197)
Ending balance at Sep. 30, 2021	830,085				$ 18			1,504,778			(82)	(674,629)
Ending balance (in shares) at Sep. 30, 2021					182,908
Beginning balance at Mar. 31, 2021	881,983				$ 18			1,491,958			56	(610,049)
Beginning balance (in shares) at Mar. 31, 2021					178,941
Vesting of restricted stock (in shares)					1,423
Exercise of stock options	333							333
Exercise of stock options (in shares)					212
Stock-based compensation expense	4,941							4,941
Unrealized gain (loss) on marketable securities, net	(43)										(43)
Net income (loss)	18,683											18,683
Ending balance at Jun. 30, 2021	905,897				$ 18			1,497,232			13	(591,366)
Ending balance (in shares) at Jun. 30, 2021					180,576
Vesting of restricted stock (in shares)					1,628
Exercise of stock options	1,596							1,596
Exercise of stock options (in shares)					704
Stock-based compensation expense	5,950							5,950
Unrealized gain (loss) on marketable securities, net	(95)										(95)
Net income (loss)	(83,263)											(83,263)
Ending balance at Sep. 30, 2021	830,085				$ 18			1,504,778			(82)	(674,629)
Ending balance (in shares) at Sep. 30, 2021					182,908
Beginning balance at Dec. 31, 2021	$ 728,502				$ 18			1,515,210			(1,366)	(785,360)
Beginning balance (in shares) at Dec. 31, 2021	184,929				184,929
Vesting of restricted stock					$ 1			(1)
Vesting of restricted stock (in shares)					1,419
Exercise of stock options	$ 652							652
Exercise of stock options (in shares)					284
Stock-based compensation expense	7,755							7,755
Unrealized gain (loss) on marketable securities, net	(3,806)										(3,806)
Net income (loss)	(31,448)											(31,448)
Ending balance at Mar. 31, 2022	701,655				$ 19			1,523,616			(5,172)	(816,808)
Ending balance (in shares) at Mar. 31, 2022					186,632
Beginning balance at Dec. 31, 2021	$ 728,502				$ 18			1,515,210			(1,366)	(785,360)
Beginning balance (in shares) at Dec. 31, 2021	184,929				184,929
Exercise of stock options (in shares)	983
Net income (loss)	$ (189,033)
Ending balance at Sep. 30, 2022	$ 566,019				$ 19			1,546,807			(6,414)	(974,393)
Ending balance (in shares) at Sep. 30, 2022	189,885				189,885
Beginning balance at Mar. 31, 2022	$ 701,655				$ 19			1,523,616			(5,172)	(816,808)
Beginning balance (in shares) at Mar. 31, 2022					186,632
Vesting of restricted stock (in shares)					1,243
Exercise of stock options	571							571
Exercise of stock options (in shares)					320
Issuance of common stock related to employee stock purchase plan	1,008							1,008
Issuance of common stock related to employee stock purchase plan, Shares					235
Stock-based compensation expense	9,911							9,911
Unrealized gain (loss) on marketable securities, net	(1,175)										(1,175)
Net income (loss)	(72,465)											(72,465)
Ending balance at Jun. 30, 2022	639,505				$ 19			1,535,106			(6,347)	(889,273)
Ending balance (in shares) at Jun. 30, 2022					188,430
Issuance of common stock, net of offering costs			$ 724							$ 724
Issuance of common stock, net of offering costs (in shares)							149
Vesting of restricted stock (in shares)					927
Exercise of stock options	897							897
Exercise of stock options (in shares)					379
Stock-based compensation expense	10,080							10,080
Unrealized gain (loss) on marketable securities, net	(67)										(67)
Net income (loss)	(85,120)											(85,120)
Ending balance at Sep. 30, 2022	$ 566,019				$ 19			$ 1,546,807			$ (6,414)	$ (974,393)
Ending balance (in shares) at Sep. 30, 2022	189,885				189,885