Condensed Consolidated Statements of Convertible Preferred Stock and Stockholders' Equity (Unaudited) - USD ($) shares in Thousands, $ in Thousands	Total	IPO	Convertible Preferred Stock	Common Stock	Common Stock IPO	Additional Paid-in Capital	Additional Paid-in Capital IPO	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Beginning balance at Dec. 31, 2020	$ (421,184)			$ 2		$ 8,216		$ 30	$ (429,432)
Beginning balance (in shares) at Dec. 31, 2020			134,113
Beginning balance at Dec. 31, 2020			$ 852,897
Beginning balance (in shares) at Dec. 31, 2020				16,170
Conversion of convertible preferred stock into common stock upon initial public offering	852,897			$ 13		852,884
Conversion of convertible preferred stock into common stock, upon initial public offering (in shares)			(134,113)
Conversion of convertible preferred stock into common stock, upon initial public offering			$ (852,897)
Conversion of convertible preferred stock into common stock, upon initial public offering (in shares)				134,113
Issuance of common stock in initial public offering, net of offering costs		$ 626,405			$ 3		$ 626,402
Issuance of common stock in initial public offering, net of offering costs (in shares)					27,025
Vesting of restricted stock (in shares)				1,428
Exercise of stock options	298					298
Exercise of stock options (in shares)				205
Stock-based compensation expense	4,158					4,158
Unrealized loss on marketable securities, net	26							26
Net loss	(180,617)								(180,617)
Ending balance at Mar. 31, 2021	881,983			$ 18		1,491,958		56	(610,049)
Ending balance (in shares) at Mar. 31, 2021				178,941
Beginning balance at Dec. 31, 2021	$ 728,502			$ 18		1,515,210		(1,366)	(785,360)
Beginning balance (in shares) at Dec. 31, 2021	184,929			184,929
Vesting of restricted stock				$ 1		(1)
Vesting of restricted stock (in shares)				1,419
Exercise of stock options	$ 652					652
Exercise of stock options (in shares)	284			284
Stock-based compensation expense	$ 7,755					7,755
Unrealized loss on marketable securities, net	(3,806)							(3,806)
Net loss	(31,448)								(31,448)
Ending balance at Mar. 31, 2022	$ 701,655			$ 19		$ 1,523,616		$ (5,172)	$ (816,808)
Ending balance (in shares) at Mar. 31, 2022	186,632			186,632