X0306 4 2022-02-18 false 0001770121 Sana Biotechnology, Inc. SANA 0001830054 MacDonald James J. C/O SANA BIOTECHNOLOGY, INC. 188 EAST BLAINE STREET, SUITE 400 SEATTLE WA 98102 false true false false EVP & General Counsel Common Stock 2021-11-15 5 A false E 1000.00 18.2325 A 429750.00 D Common Stock 2022-02-18 4 S false 333.00 6.28 D 429417.00 D Common Stock 7812.00 I Held by The James J. MacDonald and Rena Chng Trust dtd 01/15/10 Common Stock 125000.00 I Held by the KOM Trust Common Stock 125000.00 I Held by the NMM Trust The reporting person is voluntarily reporting the acquisition of shares of common stock of Sana Biotechnology, Inc. (the "Issuer") pursuant to the Sana Biotechnology, Inc. 2021 Employee Stock Purchase Plan ("ESPP") for the ESPP purchase period of February 3, 2021 through November 15, 2021. This transaction is exempt under Rule 16b-3(c). In accordance with the ESPP, these shares were purchased based on 85% of the closing price of the Issuer's common stock on November 15, 2021. The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 4, 2021. /s/ James J. MacDonald 2022-02-23