Consolidated Statements of Stockholders' Equity - USD ($) shares in Thousands, $ in Thousands	Total	At The Market Offering	Pre-Funded Warrants	Common Stock	Common Stock At The Market Offering	Common Stock Pre-Funded Warrants	Additional Paid-in Capital	Additional Paid-in Capital At The Market Offering	Additional Paid-in Capital Pre-Funded Warrants	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Beginning balance at Dec. 31, 2022	$ 499,315			$ 19			$ 1,558,459			$ (4,327)	$ (1,054,836)
Beginning balance (in shares) at Dec. 31, 2022				191,022
Issuance of common stock, net of offering costs		$ 27,020			$ 1			$ 27,019
Issuance of common stock, net of offering costs (in shares)					4,586
Vesting of restricted stock (in shares)				443
Exercise of stock options	2,020						2,020
Exercise of stock options (in shares)				1,146
Issuance of common stock related to employee stock purchase plan	2,606						2,606
Issuance of common stock related to employee stock purchase plan, Shares				660
Stock-based compensation expense	35,533						35,533
Unrealized gain on marketable securities, net	4,267									4,267
Net Income (Loss)	(283,255)										(283,255)
Ending balance at Dec. 31, 2023	287,506			$ 20			1,625,637			(60)	(1,338,091)
Ending balance (in shares) at Dec. 31, 2023				197,857
Issuance of common stock, net of offering costs		992	$ 180,008			$ 2		992	$ 180,006
Issuance of common stock, net of offering costs (in shares)					150	21,773
Vesting of restricted stock (in shares)				966
Exercise of stock options	9,493						9,493
Exercise of stock options (in shares)				2,643
Issuance of common stock related to employee stock purchase plan	1,512						1,512
Issuance of common stock related to employee stock purchase plan, Shares				534
Stock-based compensation expense	37,678						37,678
Unrealized gain on marketable securities, net	74									74
Net Income (Loss)	(266,759)										(266,759)
Ending balance at Dec. 31, 2024	$ 250,504			$ 22			1,855,318			14	(1,604,850)
Ending balance (in shares) at Dec. 31, 2024	223,923			223,923
Issuance of common stock, net of offering costs		$ 45,767	$ 80,625		$ 2	$ 2		$ 45,765	$ 80,623
Issuance of common stock, net of offering costs (in shares)					11,298	24,254
Exercise of pre-funded warrants (in shares)				4,445
Vesting of restricted stock				$ 0
Vesting of restricted stock (in shares)				1,514
Exercise of stock options	$ 2,326			$ 1			2,325
Exercise of stock options (in shares)	978			1,059
Issuance of common stock related to employee stock purchase plan	$ 350						350
Issuance of common stock related to employee stock purchase plan, Shares				239
Stock-based compensation expense	25,464						25,464
Unrealized gain on marketable securities, net	14									14
Net Income (Loss)	(244,166)										(244,166)
Ending balance at Dec. 31, 2025	$ 160,884			$ 27			$ 2,009,845			$ 28	$ (1,849,016)
Ending balance (in shares) at Dec. 31, 2025	266,732			266,732