Commitments and Contingencies (Tables)

12 Months Ended

Dec. 31, 2025

Commitments and Contingencies Disclosure [Abstract]

Schedule of Additional Information Related to Operating Leases

The following table contains additional information related to the Company’s operating leases:

Location	Use	Approximate Square Footage	Commencement Dates	Expiration Dates
Seattle, WA	Office/Laboratory	48,000	March 2019 to September 2020	December 2026 to April 2028
Cambridge, MA	Office/Laboratory	56,000	March 2019 to January 2020	June 2027 to February 2028
South San Francisco, CA	Office/Laboratory	99,000	December 2019 to April 2022	April 2030
Rochester, NY	Office/Laboratory	3,000	January 2022	January 2027
Bothell, WA	Office/Laboratory/Manufacturing	80,000	January 2023	January 2039

Summary of Lease Costs

The following table summarizes the Company’s lease costs:

	Year Ended December 31,
	2025		2024		2023
	(in thousands)
Operating lease cost	$	25,024	$	18,540	$	27,277
Short-term lease cost		3,576		4,669		-
Variable lease cost		8,442		8,505		7,527
Total lease cost	$	37,042	$	31,714	$	34,804

Reconciliation of Undiscounted Operating Lease Cash Flows by Fiscal Year to Present Value of Operating Lease Liabilities

The following table reconciles the Company’s undiscounted operating lease cash flows by fiscal year to the present value of the operating lease liabilities as of December 31, 2025 (in thousands):

2026	$	22,473
2027		19,390
2028		14,698
2029		14,071
2030		7,758
2031 and thereafter		40,942
Total undiscounted lease payments		119,332
Less: imputed interest		(40,470	)
Present value of operating lease liabilities		78,862
Less: current portion of operating lease liabilities	$	(14,938	)
Operating lease liabilities, net of current portion	$	63,924