Segment reporting (Tables)

12 Months Ended

Dec. 31, 2025

Segment Reporting [Abstract]

Summary of Segment Loss Including Segment Expenses

The table below is a summary of the segment loss, including significant segment expenses (in thousands):

	Twelve months ended December 31,
	2025			2024			2023
Operating expenses:
Research, development, and laboratory	$	45,696		$	86,522		$	112,567
Facility costs		44,253			49,429			54,778
Support functions		29,425			45,587			54,355
Stock-based compensation		25,464			37,678			35,533
Technical operations and manufacturing		21,813			39,713			52,359
Portfolio prioritization costs		318			5,840			5,203
Other(1)		9,307			14,944			20,313
Research and development related success payments and contingent consideration		29,432			(8,881	)		(48,981	)
Impairment of long-lived assets		44,611			1,891			7,014
Total operating expenses		250,319			272,723			293,141
Loss from operations		(250,319	)		(272,723	)		(293,141	)
Interest income, net		3,848			10,471			9,938
Other income (expense), net		2,305			(4,507	)		(52	)
Net loss	$	(244,166	)	$	(266,759	)	$	(283,255	)

(1) Other segment expenses include licensing costs, consulting fees, business taxes, and insurance costs for the years ended December 31, 2025, 2024, and 2023, and costs incurred for the early termination of the Fremont lease for the year ended December 31, 2023.