Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2025	Sep. 30, 2024
OPERATING ACTIVITIES:
Net loss	$ (185,341)	$ (217,690)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	9,697	11,698
Stock-based compensation expense	19,127	31,242
Change in the estimated fair value of contingent consideration	6,173	2,250
Change in the estimated fair value of success payment liabilities	9,170	2,316
Non-cash expense for operating lease right-of-use assets	6,780	7,501
Impairment of long-lived assets	44,611	0
Other non-cash items, net	(7,876)	(7,853)
Changes in operating assets and liabilities:
Prepaid expenses and other assets	1,861	(6,781)
Operating lease right-of-use assets and liabilities	(1,539)	7,591
Accounts payable	(3,356)	(904)
Accrued expenses and other liabilities	(10,494)	(5,362)
Net cash used in operating activities	(111,187)	(175,992)
INVESTING ACTIVITIES:
Purchases of marketable securities	(51,209)	(212,988)
Proceeds from maturities of marketable securities	26,761	216,347
Purchases of property and equipment	(65)	(32,994)
Proceeds from disposal of assets	771	0
Net cash used in investing activities	(23,742)	(29,635)
FINANCING ACTIVITIES:
Proceeds from employee stock purchase plan and exercise of stock options	1,617	10,306
Proceeds related to common stock financings, net	109,724	181,000
Proceeds (principal payments), net for tenant improvement loan	(258)	7,800
Net cash provided by financing activities	111,083	199,106
Net decrease in cash, cash equivalents, and restricted cash	(23,846)	(6,521)
Cash, cash equivalents, and restricted cash at beginning of period	131,398	137,349
Cash, cash equivalents, and restricted cash at end of period	107,552	130,828
SUPPLEMENTAL CASH FLOW INFORMATION:
Purchases of property and equipment included in accounts payable and accrued liabilities	0	258
Cash received for tenant improvement allowances	891	7,344
Derecognition of operating lease right-of-use asset for lease modification	$ (2,724)	$ (6,362)