Income Taxes - Components of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2024	Dec. 31, 2023
Deferred tax assets:
Net operating loss carryforwards	$ 227,866	$ 192,179
Capitalized research and development	101,732	101,136
Tax credit carryforwards	81,697	69,070
Lease liabilities	24,040	31,503
Stock-based compensation	13,258	12,607
Intangibles	8,902	10,744
Accrued liabilities and allowances	4,329	6,050
Fixed assets	1,935	1,073
Success payment liabilities	82	496
Other	1,475	285
Gross deferred tax assets	465,316	425,143
Valuation allowance	(450,666)	(402,658)
Deferred tax assets, net of valuation allowance	14,650	22,485
Deferred tax liabilities:
Right-of-use assets	$ (14,650)	$ (22,485)