Consolidated Statements of Stockholders' Equity - USD ($) shares in Thousands, $ in Thousands	Total	At The Market Offering	Common Stock	Common Stock At The Market Offering	Additional Paid-in Capital	Additional Paid-in Capital At The Market Offering	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Beginning balance at Dec. 31, 2021	$ 728,502		$ 18		$ 1,515,210		$ (1,366)	$ (785,360)
Beginning balance (in shares) at Dec. 31, 2021			184,929
Issuance of common stock, net of offering costs		$ 601				$ 601
Issuance of common stock, net of offering costs (in shares)				149
Vesting of restricted stock	1		$ 1
Vesting of restricted stock (in shares)			4,395
Exercise of stock options	2,253				2,253
Exercise of stock options (in shares)			1,062
Issuance of common stock related to employee stock purchase plan	2,058				2,058
Issuance of common stock related to employee stock purchase plan, Shares			487
Stock-based compensation expense	38,337				38,337
Unrealized gain (loss) on marketable securities, net	(2,961)						(2,961)
Net Income (Loss)	(269,476)							(269,476)
Ending balance at Dec. 31, 2022	499,315		$ 19		1,558,459		(4,327)	(1,054,836)
Ending balance (in shares) at Dec. 31, 2022			191,022
Issuance of common stock, net of offering costs		27,020		$ 1		27,019
Issuance of common stock, net of offering costs (in shares)				4,586
Vesting of restricted stock (in shares)			443
Exercise of stock options	2,020				2,020
Exercise of stock options (in shares)			1,146
Issuance of common stock related to employee stock purchase plan	2,606				2,606
Issuance of common stock related to employee stock purchase plan, Shares			660
Stock-based compensation expense	35,533				35,533
Unrealized gain (loss) on marketable securities, net	4,267						4,267
Net Income (Loss)	(283,255)							(283,255)
Ending balance at Dec. 31, 2023	$ 287,506		$ 20		1,625,637		(60)	(1,338,091)
Ending balance (in shares) at Dec. 31, 2023	197,857		197,857
Issuance of common stock, net of offering costs	$ 180,008	$ 992	$ 2		180,006	$ 992
Issuance of common stock, net of offering costs (in shares)			21,773	150
Vesting of restricted stock (in shares)			966
Exercise of stock options	$ 9,493				9,493
Exercise of stock options (in shares)	2,631		2,643
Issuance of common stock related to employee stock purchase plan	$ 1,512				1,512
Issuance of common stock related to employee stock purchase plan, Shares			534
Stock-based compensation expense	37,678				37,678
Unrealized gain (loss) on marketable securities, net	74						74
Net Income (Loss)	(266,759)							(266,759)
Ending balance at Dec. 31, 2024	$ 250,504		$ 22		$ 1,855,318		$ 14	$ (1,604,850)
Ending balance (in shares) at Dec. 31, 2024	223,923		223,923