Organization - Additional Information (Details) - USD ($) shares in Thousands	1 Months Ended		12 Months Ended
	Nov. 30, 2024	Feb. 29, 2024	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022	Aug. 31, 2022
Description Of Organization [Line Items]
Stock-based compensation expense			$ 37,678,000	$ 35,533,000	$ 38,337,000
Percentage of workforce reduction	45.00%
Cash-based expenses related to employee severance, benefits and related costs			5,800,000
Accumulated deficit			1,604,850,000	$ 1,338,091,000
Cash, cash equivalents and marketable securities			152,500,000
Success payment liabilities			2,100,000
Contingent consideration			$ 57,700,000
Common Stock
Description Of Organization [Line Items]
Aggregate common stock sold			21,773
At The Market Offering | Common Stock
Description Of Organization [Line Items]
Aggregate common stock sold			150	4,586	149
Underwritten Public Offering [Member] | Common Stock
Description Of Organization [Line Items]
Aggregate common stock sold		21,800
Underwritten Public Offering
Description Of Organization [Line Items]
Net proceeds from issuance of common stock		$ 180,000,000	$ 180,000,000
Number of warrants to purchase common stock		12,700
Underwriters' Option To Purchase Additional Shares | Common Stock
Description Of Organization [Line Items]
Aggregate common stock sold		4,500
Cowen | At The Market Offering
Description Of Organization [Line Items]
Common stock maximum aggregate offering price						$ 150,000,000
Net proceeds from issuance of common stock			$ 28,600,000
Aggregate common stock sold			4,900