Consolidated Statements of Convertible Preferred Stock and Stockholders' Equity (Deficit) - USD ($) shares in Thousands, $ in Thousands	Total	At The Market Offering	Convertible Preferred Stock	Common Stock	Common Stock IPO	Common Stock At The Market Offering	Additional Paid-in Capital	Additional Paid-in Capital At The Market Offering	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Beginning balance at Dec. 31, 2020	$ (421,184)			$ 2			$ 8,216		$ 30	$ (429,432)
Beginning balance (in shares) at Dec. 31, 2020			134,113
Beginning balance at Dec. 31, 2020			$ 852,897
Beginning balance (in shares) at Dec. 31, 2020				16,170
Conversion of convertible preferred stock into common stock upon initial public offering	852,897			$ 13			852,884
Conversion of convertible preferred stock into common stock, upon initial public offering (in shares)			(134,113)
Conversion of convertible preferred stock into common stock, upon initial public offering			$ (852,897)
Conversion of convertible preferred stock into common stock, upon initial public offering (in shares)				134,113
Issuance of common stock, net of offering costs	626,405				$ 3		626,402
Issuance of common stock, net of offering costs (in shares)					27,025
Vesting of restricted stock (in shares)				5,916
Stock-based compensation	22,362						22,362
Exercise of stock options	3,167						3,167
Exercise of stock options (in shares)				1,586
Issuance of common stock related to employee stock purchase plan	2,179						2,179
Issuance of common stock related to employee stock purchase plan, Shares				119
Unrealized gain (loss) on marketable securities, net	(1,396)								(1,396)
Net Income (Loss)	(355,928)									(355,928)
Ending balance at Dec. 31, 2021	728,502			$ 18			1,515,210		(1,366)	(785,360)
Ending balance (in shares) at Dec. 31, 2021				184,929
Issuance of common stock, net of offering costs		$ 601						$ 601
Issuance of common stock, net of offering costs (in shares)						149
Vesting of restricted stock	1			$ 1
Vesting of restricted stock (in shares)				4,395
Stock-based compensation	38,337						38,337
Exercise of stock options	2,253						2,253
Exercise of stock options (in shares)				1,062
Issuance of common stock related to employee stock purchase plan	2,058						2,058
Issuance of common stock related to employee stock purchase plan, Shares				487
Unrealized gain (loss) on marketable securities, net	(2,961)								(2,961)
Net Income (Loss)	(269,476)									(269,476)
Ending balance at Dec. 31, 2022	$ 499,315			$ 19			1,558,459		(4,327)	(1,054,836)
Ending balance (in shares) at Dec. 31, 2022	191,022			191,022
Issuance of common stock, net of offering costs		$ 27,020				$ 1		$ 27,019
Issuance of common stock, net of offering costs (in shares)						4,586
Vesting of restricted stock (in shares)				443
Stock-based compensation	$ 35,533						35,533
Exercise of stock options	$ 2,020						2,020
Exercise of stock options (in shares)	1,146			1,146
Issuance of common stock related to employee stock purchase plan	$ 2,606						2,606
Issuance of common stock related to employee stock purchase plan, Shares				660
Unrealized gain (loss) on marketable securities, net	4,267								4,267
Net Income (Loss)	(283,255)									(283,255)
Ending balance at Dec. 31, 2023	$ 287,506			$ 20			$ 1,625,637		$ (60)	$ (1,338,091)
Ending balance (in shares) at Dec. 31, 2023	197,857			197,857