Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
OPERATING ACTIVITIES:
Net loss	$ (195,138)	$ (189,033)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	13,293	11,430
Stock-based compensation expense	27,602	27,746
Change in the estimated fair value of contingent consideration	(47,223)	(12,613)
Change in the estimated fair value of success payment liabilities	(8,593)	(66,815)
Non-cash expense for operating lease right-of-use assets	10,031	8,859
Other non-cash items, net	(9,962)	(6,687)
Changes in operating assets and liabilities:
Prepaid expenses and other assets	5,560	569
Operating lease right-of-use assets and liabilities	2,129	1,584
Accounts payable	2,363	2,144
Accrued expenses and other liabilities	(1,685)	8,833
Net cash used in operating activities	(201,623)	(213,983)
INVESTING ACTIVITIES:
Purchases of marketable securities	(131,617)	(63,583)
Proceeds from maturities of marketable securities	294,305	201,991
Purchases of property and equipment	(5,986)	(16,274)
Net cash provided by investing activities	156,702	122,134
FINANCING ACTIVITIES:
Proceeds from issuance of common stock, net	2,919	3,128
Net cash provided by financing activities	29,928	3,852
Net decrease in cash, cash equivalents, and restricted cash	(14,993)	(87,997)
Cash, cash equivalents, and restricted cash at beginning of period	187,273	261,848
Cash, cash equivalents, and restricted cash at end of period	172,280	173,851
SUPPLEMENTAL CASH FLOW INFORMATION:
Operating lease right-of-use assets obtained in exchange for lease obligations	8,984	21,073
Purchases of property and equipment included in accounts payable and accrued liabilities	9,933	2,409
Cash received for amounts related to tenant improvement allowances	2,298	2,014
Derecognition of operating lease right-of-use asset for lease termination	(14,204)	(12,801)
At The Market Offering
FINANCING ACTIVITIES:
Proceeds from issuance of common stock, net	$ 27,009	$ 724