Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
OPERATING ACTIVITIES:
Net loss	$ (196,122)	$ (103,913)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	8,794	7,414
Stock-based compensation expense	18,599	17,666
Change in the estimated fair value of contingent consideration	11,355	(4,358)
Change in the estimated fair value of success payment liabilities	15,444	(69,008)
Non-cash expense for operating lease right-of-use assets	6,755	5,682
Other non-cash items, net	(6,088)	(3,726)
Changes in operating assets and liabilities:
Prepaid expenses and other assets	5,428	(657)
Operating lease right-of-use assets and liabilities	1,444	111
Accounts payable	87	663
Accrued expenses and other liabilities	(3,769)	939
Net cash used in operating activities	(138,073)	(149,187)
INVESTING ACTIVITIES:
Purchases of marketable securities	(71,267)	(45,961)
Proceeds from maturities of marketable securities	180,374	148,160
Purchases of property and equipment	(3,753)	(11,924)
Net cash provided by investing activities	105,354	90,275
FINANCING ACTIVITIES:
Proceeds from issuance of common stock, net	2,727	2,231
Net cash provided by financing activities	29,741	2,231
Net decrease in cash, cash equivalents, and restricted cash	(2,978)	(56,681)
Cash, cash equivalents, and restricted cash at beginning of period	187,273	261,848
Cash, cash equivalents, and restricted cash at end of period	184,295	205,167
SUPPLEMENTAL CASH FLOW INFORMATION:
Operating lease right-of-use assets obtained in exchange for lease obligations	8,984	21,073
Purchases of property and equipment included in accounts payable and accrued liabilities	1,953	3,346
Cash received for amounts related to tenant improvement allowances	1,198	541
Remeasurement of operating lease right-of-use asset for lease modification		$ (12,801)
At The Market Offering
FINANCING ACTIVITIES:
Proceeds from issuance of common stock, net	$ 27,014