Condensed Consolidated Statements of Stockholders' Equity (Unaudited) - USD ($) shares in Thousands, $ in Thousands	Total	At The Market Offering	Common Stock	Additional Paid-in Capital	Additional Paid-in Capital At The Market Offering	Accumulated Other Comprehensive Loss	Accumulated Deficit
Beginning balance at Dec. 31, 2021	$ 728,502		$ 18	$ 1,515,210		$ (1,366)	$ (785,360)
Beginning balance (in shares) at Dec. 31, 2021			184,929
Vesting of restricted stock			$ 1	(1)
Vesting of restricted stock (in shares)			1,419
Exercise of stock options	652			652
Exercise of stock options (in shares)			284
Stock-based compensation expense	7,755			7,755
Unrealized gain (loss) on marketable securities, net	(3,806)					(3,806)
Net income (loss)	(31,448)						(31,448)
Ending balance at Mar. 31, 2022	701,655		$ 19	1,523,616		(5,172)	(816,808)
Ending balance (in shares) at Mar. 31, 2022			186,632
Beginning balance at Dec. 31, 2021	728,502		$ 18	1,515,210		(1,366)	(785,360)
Beginning balance (in shares) at Dec. 31, 2021			184,929
Net income (loss)	(103,913)
Ending balance at Jun. 30, 2022	639,505		$ 19	1,535,106		(6,347)	(889,273)
Ending balance (in shares) at Jun. 30, 2022			188,430
Beginning balance at Mar. 31, 2022	701,655		$ 19	1,523,616		(5,172)	(816,808)
Beginning balance (in shares) at Mar. 31, 2022			186,632
Vesting of restricted stock (in shares)			1,243
Exercise of stock options	571			571
Exercise of stock options (in shares)			320
Issuance of common stock related to employee stock purchase plan	1,008			1,008
Issuance of common stock related to employee stock purchase plan, Shares			235
Stock-based compensation expense	9,911			9,911
Unrealized gain (loss) on marketable securities, net	(1,175)					(1,175)
Net income (loss)	(72,465)						(72,465)
Ending balance at Jun. 30, 2022	639,505		$ 19	1,535,106		(6,347)	(889,273)
Ending balance (in shares) at Jun. 30, 2022			188,430
Beginning balance at Dec. 31, 2022	$ 499,315		$ 19	1,558,459		(4,327)	(1,054,836)
Beginning balance (in shares) at Dec. 31, 2022	191,022		191,022
Fees incurred related to issuance of common stock from at the market offering		$ (200)			$ (200)
Vesting of restricted stock (in shares)			154
Exercise of stock options	$ 331			331
Exercise of stock options (in shares)			233
Stock-based compensation expense	8,751			8,751
Unrealized gain (loss) on marketable securities, net	2,188					2,188
Net income (loss)	(82,123)						(82,123)
Ending balance at Mar. 31, 2023	428,262		$ 19	1,567,341		(2,139)	(1,136,959)
Ending balance (in shares) at Mar. 31, 2023			191,409
Beginning balance at Dec. 31, 2022	$ 499,315		$ 19	1,558,459		(4,327)	(1,054,836)
Beginning balance (in shares) at Dec. 31, 2022	191,022		191,022
Exercise of stock options (in shares)	590
Net income (loss)	$ (196,122)
Ending balance at Jun. 30, 2023	$ 355,029		$ 20	1,606,832		(865)	(1,250,958)
Ending balance (in shares) at Jun. 30, 2023	196,880		196,880
Beginning balance at Mar. 31, 2023	$ 428,262		$ 19	1,567,341		(2,139)	(1,136,959)
Beginning balance (in shares) at Mar. 31, 2023			191,409
Fees incurred related to issuance of common stock from at the market offering		(985)
Vesting of restricted stock (in shares)			119
Exercise of stock options	691			691
Exercise of stock options (in shares)			357
Issuance of common stock related to employee stock purchase plan	1,705			1,705
Issuance of common stock related to employee stock purchase plan, Shares			409
Stock-based compensation expense	9,848			9,848
Unrealized gain (loss) on marketable securities, net	1,274					1,274
Net income (loss)	(113,999)						(113,999)
Issuance of common stock, net of offering costs (in shares)			4,586
Issuance of common stock, net of offering costs	27,248	$ 27,247	$ 1
Ending balance at Jun. 30, 2023	$ 355,029		$ 20	$ 1,606,832		$ (865)	$ (1,250,958)
Ending balance (in shares) at Jun. 30, 2023	196,880		196,880