X0202 SCHEDULE 13D/A 0001388325-25-000021 0001388325 XXXXXXXX LIVE 1 Voting Common Stock, par value $0.0001 per share 07/30/2026 false 0001770069 56565P103 MAPLIGHT THERAPEUTICS, INC.

800 Chesapeake Drive Redwood City CA 94063

Barbara Fiorini 45 3527 6592 Novo Holdings A/S, Tuborg Havnevej 19 Hellerup G7 DK-2900 0001388325 N Novo Holdings A/S AF WC N G7 2086622.00 0.00 2086622.00 0.00 2086622.00 N 4.9 CO Voting Common Stock, par value $0.0001 per share MAPLIGHT THERAPEUTICS, INC. 800 Chesapeake Drive Redwood City CA 94063 This Amendment No. 1 (this "Amendment No. 1" or this "Schedule 13D/A") amends and supplements the statement on Schedule 13D originally filed with the Securities and Exchange Commission (the "SEC") on November 4, 2025 (the "Statement") by the Reporting Persons. Unless otherwise defined herein, capitalized terms used in this Amendment No. 1 shall have the meanings ascribed to them in the Statement. Unless amended or supplemented below, the information in the Statement remains unchanged. Novo Holdings A/S beneficially owns 2,086,622 shares of common stock representing approximately 4.9% of the Issuer's outstanding shares of common stock (the "Novo Shares"), based upon 42,618,165 shares of common stock outstanding as of May 7, 2026, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on May 14, 2026. Novo Holdings A/S is a Danish corporation wholly owned by the Foundation. Novo Holdings A/S has the sole power to vote and dispose of the Novo Shares. Neither the Foundation nor any person listed on Schedule I has the power to direct the vote as to, or the disposition of the Novo Shares. Except as set forth below, Novo Holdings A/S has not effected any transactions with respect to the Issuer's common stock during the past sixty days and neither the Foundation nor any person listed on Schedule I has effected any transactions in the Issuer's Common Stock within the past 60 days. On July 30, 2026, Novo Holdings A/S sold the following shares in open market transactions: - 1,314,195 shares of common stock in a single transaction at a price of $12.00 per share; - 220,723 shares of common stock at prices ranging from $13.55 to $14.54 per share (a weighted-average price of $14.19 per share); and - 65,082 shares of common stock at prices ranging from $14.55 to $15.00 per share (a weighted-average price of $14.69 per share). Novo Holdings A/S does not know of any other person having the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the Novo Shares. The Reporting Persons ceased to be the beneficial owners of more than five percent of the common stock on July 30, 2026. Exhibit 99.1 Schedule I Novo Holdings A/S /s/ Barbara Fiorini 07/31/2026