144 0001388325 XXXXXXXX LIVE 0001770069 MAPLIGHT THERAPEUTICS, INC. 001-42914 800 CHESAPEAKE DRIVE REDWOOD CITY CA 94063 (617) 984-6300 Novo Holdings A/S Former Affiliate Voting Common Stock Morgan Stanley & Co. LLC

1585 Broadway New York NY 10036

1600000 24032000 45345676 07/30/2026 Nasdaq Global Select Voting Common Stock 10/20/2023 Direct Investment Issuer N 727533 10/20/2023 Cash Voting Common Stock 03/27/2024 Direct Investment Issuer N 831466 03/27/2024 Cash Voting Common Stock 07/18/2025 Direct Investment Issuer N 41001 07/18/2025 Cash Y 07/30/2026 Novo Holdings A/S, By /s/ Barbara Fiorini, General Counsel, Finance & Operations