<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2019-07-19</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001615219</issuerCik>
        <issuerName>Salarius Pharmaceuticals, Inc.</issuerName>
        <issuerTradingSymbol>SLRX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001769331</rptOwnerCik>
            <rptOwnerName>Arthur David J.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O SALARIUS PHARMACEUTICALS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>2450 HOLCOMBE BLVD., SUITE J-608</rptOwnerStreet2>
            <rptOwnerCity>HOUSTON</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>77021</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Executive Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>79371</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Received in connection with the Issuer's business combination (the &quot;Merger&quot;) with Salarius Pharmaceuticals, LLC (&quot;Private Salarius&quot;) in accordance with the terms of the Agreement and Plan of Merger dated as of January 3, 2019 and amended on June 27, 2019, by and among Issuer, Falcon Acquisition Sub, LLC and Private Salarius, in exchange for 79,371 shares of common stock of Private Salarius.</footnote>
        <footnote id="F2">4,783 shares of the Common Stock are restricted stock.</footnote>
    </footnotes>

    <remarks>Exhibit List: Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ David J. Arthur</signatureName>
        <signatureDate>2019-07-23</signatureDate>
    </ownerSignature>
</ownershipDocument>
