X0306 4 2019-03-01 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001769127 CATHERS BRIAN EDWIN C/O GLOBAL BLOOD THERAPEUTICS, INC. 171 OYSTER POINT BLVD., SUITE 300 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 See Remarks Stock Option (Right to Buy) 53.48 2019-03-01 4 A 0 45000 0.00 A 2029-02-28 Common Stock 45000 45000 D Restricted Stock Units 2019-03-01 4 A 0 30000 0.00 A Common Stock 30000 30000 D Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's Common Stock. The shares of Common Stock underlying the option shall vest with respect to 1/4th of the shares on February 25, 2020 and thereafter 1/12th of the remaining underlying shares shall vest in equal quarterly installments over 3 years from February 25, 2020, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. This option is subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The shares of Common Stock underlying the RSUs shall vest with respect to 1/4th of the shares on March 1, 2020 and thereafter 1/6th of the remaining underlying shares shall vest in semi-annual installments over 3 years from March 1, 2020, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. Chief Scientific Officer /s/ Lesley Ann Calhoun, as Attorney-in-Fact 2019-03-05