March 28, 2019


Bissie K. Bonner
Willkie, Farr & Gallagher LLP
787 Seventh Avenue
New York, New York 10019-6099

Re:    BlackRock Science and Technology Trust II
       SEC File Numbers: 333-229897; 811-2328

Dear Ms. Bonner:

        We have reviewed the registration statement of BlackRock Science and
Technology Trust II, (the "Fund") filed on February 27, 2019 on Form N-2 under
the Securities
Act of 1933 (the "1933 Act") and the Investment Company Act of 1940. The Fund
filed the
registration statement to register common shares. We have the following
comments.

                                            Prospectus

Cover Page

       1. Limited Term and Eligible Tender Offer, Please put the last three
sentences of this
paragraph about this Trust not being a "target date", "target term" or "life
cycle" fund in bold.

                                       Prospectus Summary

Limited Term and Eligible Tender Offer, pages 1-3

        2. Please print in bold the last paragraph under this heading that
states that the Fund is
not a "target term", "target date", or "life cycle" fund.

Summary of Trust Expenses, pages 34-35

       3. Please confirm in your response letter to the staff that short
expenses (i.e., dividends
paid on the stocks sold short) are in the fee table.
       4. The prospectus states that the Fund can invest in open- or closed-end
investment
companies, including exchange-traded funds and business development companies.
The fee table
does not include a line item for Acquired Fund Fees and Expenses ("AFFE"). In
the event the
AFFE incurred exceeds 0.01% of the average net assets of the Fund, please
include these fees
and expenses in a separate line in the fee table.
                                                   2


       5. Please furnish the staff a completed fee table at least a week before
acceleration is
requested for this filing. We may have further comments.
                         Statement of Additional Information ("SAI")

Management of the Trust, pages S-33   S-35

        6. The information about the Trustees and portfolio managers should be
furnished by a
pre-effective amendment.

                                       General Comments

       7. Where a comment is made in one location, it is applicable to all
similar disclosure
appearing elsewhere in the registration statement.

        8. We note that portions of the filing are incomplete. We may have
additional comments
on such portions when you complete them in a pre-effective amendment, on
disclosures made in
response to this letter, on information supplied supplementally, or on exhibits
added in any pre-
effective amendments.

       9. Please advise us if you have submitted or expect to submit an
exemptive application
or no-action request in connection with your registration statement.

       10. If the Fund intends to rely on Rule 430A under the 1933 Act to omit
certain
information from the prospectus included with the final pre-effective
amendment, please identify
the omitted information to us supplementally, before filing the Fund's final
pre-effective
amendment.

        Responses to this letter should be in the form of a pre-effective
amendment filed
pursuant to Rule 472 under the 1933 Act. Where no change will be made in the
filing in response
to a comment, please indicate this fact in a supplemental letter and briefly
state the basis for your
position.

       In closing, we remind you that the Fund and its management are
responsible for the
accuracy and adequacy of their disclosures, notwithstanding any review,
comments, action or
absence of action by the staff.

       Please contact the undersigned at (202) 551-6961 should you have any
questions
regarding this letter.

                                        Sincerely,

                                       /s/ John Grzeskiewicz

                                        John Grzeskiewicz
                                        Senior Counsel
 3